老年骨质疏松症早期干预治疗69例的临床研究

目的分析老年骨质疏松症早期干预治疗的临床效果,探讨骨密度(BMD)检测对治疗的重要性。方法 69例患者经骨密度检测确诊老年骨质疏松症,给予药物、营养饮食综合治疗,然后比较治疗前后临床有效率,临床有效率根据有效的患者数/总治疗患者数;临床有效判断根据临床疼痛、乏力症状消失,X线无新发骨折。检测不同部位BMD、血钙、血磷、碱性磷酸酶(AKP)。结果临床治疗有效率达98.6%。治疗后监测BMD所有部位骨量丢失明显减少均较治疗前显著增加,差异有统计学意义(均P0.05);血钙、血磷、碱性磷酸酶(AKP)结果较治疗前降低,比较有统计学意义(P0.05)。X线比较治疗后无再发椎体压缩骨折。结论早期干预治疗老年骨质疏松症临床效果显著。骨密度和生化指标检测是早期老年骨质疏松风险预测、评价早期干预治疗后疗效的重要指标和敏感方法。

The clinical study of early intervention for senile osteoporosis in 69 cases

Objective To analyze the clinical effect of early intervention for senile osteoporosis, and to investigate the importance of bone mineral density (BMD) for the treatment. Methods After the detection of BMD, 69 patients were diagnosed with senile osteoporosis. All the patients were given a comprehensive treatment including drugs and nutritional diet. The clinical efficacy before and after the treatment was compared. The clinical effective rate was defined as the number of effective patients /the number of total patients. The clinical effectiveness was defined as disappearance of pain and fatigue and no new fracture in X-ray images. BM D of different location, blood calcium, phosphorus, and alkaline phosphatase (AKP) were detected. Results The clinical effective rate was 98. 6% . After the treatment, the detection of BMD showed that the loss of bone mass in all parts decreased significantly than that before the treatment (P <0. 05) . The concentrations of blood calcium, phosphate, and AKP were significantly lower than that before the treatment (P <0. 05) . No occurrence of new vertebral compression fractures in X-*ay images was observed after the treatment. Conclusion The clinical effect of early intervention for senile osteoporosis is remarkable. BMD and biochemical indexes were important factors for risk prediction of early senile osteoporosis and the evaluation of the clinical effect of early intervention.