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Apomorphine effect on pain threshold in Parkinson's disease: A clinical and positron emission tomography study |
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| Authors: | Estelle Dellapina MSc Angélique Gerdelat‐Mas MD Fabienne Ory‐Magne MD Laure Pourcel MSc Monique Galitzky MD Fabienne Calvas MD Marion Simonetta‐Moreau MD PhD Claire Thalamas MD Pierre Payoux MD PhD Christine Brefel‐Courbon MD |
| Affiliation: | 1. Inserm, Imagerie cérébrale et handicaps neurologiques, Toulouse, France;2. Université de Toulouse, UPS, Imagerie cérébrale et handicaps neurologiques, Toulouse, France;3. Centre Hospitalier Universitaire de Toulouse, Service de Neurologie, Toulouse, France;4. Unité de Pharmacoépidémiologie, Faculté de médecine, Toulouse, France;5. Inserm, Centre d'Investigation Clinique, CHU Purpan, Toulouse, France;6. Service de Pharmacologie Clinique, Faculté de médecine, Toulouse, France |
| Abstract: | Patients with Parkinson's disease (PD) frequently experience pain that could be in part due to central modification of nociception. In this randomized controlled double blind study, we compared the effect of apomorphine versus placebo on pain thresholds and pain‐induced cerebral activity in 25 patients with PD. Subjective pain threshold (using thermal stimulation, thermotest), objective pain threshold (nociceptive flexion reflex), and cerebral activity (H O PET) during noxious and innocuous stimulations were performed. Neither subjective nor objective pain thresholds nor pain activation profile were modified by apomorphine compared with placebo in 25 PD patients. Apomorphine has no effect on pain processing in PD. We suggest that other monoamine systems than dopaminergic system could be involved. © 2010 Movement Disorder Society. |
| Keywords: | Parkinson's disease pain threshold HO positron emission tomography apomorphine |