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Influence of cell cycle phase on apparent diffusion coefficient in synchronized cells detected using temporal diffusion spectroscopy |
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| Authors: | Junzhong Xu Jingping Xie Jerome Jourquin Daniel C. Colvin Mark D. Does Vito Quaranta John C. Gore |
| Affiliation: | 1. Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, Tennessee, USA;2. Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, Tennessee, USA;3. Department of Cancer Biology, Vanderbilt University, Nashville, Tennessee, USA;4. Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee, USA;5. Department of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, Tennessee, USA;6. Department of Physics and Astronomy, Vanderbilt University, Nashville, Tennessee, USA;7. Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA |
| Abstract: | The relationship between the apparent diffusion coefficient of tissue water measured by MR methods and the physiological status of cells is of particular relevance for better understanding and interpretation of diffusion‐weighted MRI. In addition, there is considerable interest in developing diffusion‐dependent imaging methods capable of providing novel information on tissue microstructure, including intracellular changes. To this end, both the conventional pulsed gradient spin–echo methods and the oscillating gradient spin–echo method, which probes diffusion over very short distance (< |
| Keywords: | diffusion oscillating gradient MRI intracellular structure cell phase cell size surface‐to‐volume ratio |