Carotid plaque assessment using fast 3D isotropic resolution black‐blood MRI |
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| Authors: | Niranjan Balu Vasily L Yarnykh Baocheng Chu Jinnan Wang Thomas Hatsukami Chun Yuan |
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| Institution: | 1. Department of Radiology, University of Washington, Seattle, Washington, USA;2. Clinical Sites Research Program, Philips Research North America, Briarcliff Manor, New York, USA;3. Department of Surgery, University of Washington, Seattle, Washington, USA |
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| Abstract: | Black‐blood MRI is a promising tool for carotid atherosclerotic plaque burden assessment and compositional analysis. However, current sequences are limited by large slice thickness. Accuracy of measurement can be improved by moving to isotropic imaging but can be challenging for patient compliance due to long scan times. We present a fast isotropic high spatial resolution (0.7 × 0.7 × 0.7 mm3) three‐dimensional black‐blood sequence (3D‐MERGE) covering the entire cervical carotid arteries within 2 min thus ensuring patient compliance and diagnostic image quality. The sequence is optimized for vessel wall imaging of the carotid bifurcation based on its signal properties. The optimized sequence is validated on patients with significant carotid plaque. Quantitative plaque morphology measurements and signal‐to‐noise ratio measures show that 3D‐MERGE provides good blood suppression and comparable plaque burden measurements to existing MRI protocols. 3D‐MERGE is a promising new tool for fast and accurate plaque burden assessment in patients with atherosclerotic plaque. Magn Reson Med, 2011. © 2010 Wiley‐Liss, Inc. |
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| Keywords: | three dimensional black‐blood carotid atherosclerotic plaque 3D‐MERGE approach to spoiled steady state MSDE SPACE snapshot FLASH diffusion preparation vessel wall imaging |
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