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Ventricular enlargement and mild cognitive impairment in early Parkinson's disease |
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| Authors: | Turi O Dalaker MD Robert Zivadinov MD PhD Deepa Preeti Ramasamy MD Mona K Beyer MD PhD Guido Alves MD PhD Kolbjorn S Bronnick PhD Ole‐Bjorn Tysnes MD PhD Dag Aarsland MD PhD Jan P Larsen MD PhD |
| Institution: | 1. Department of Radiology, Stavanger University Hospital, Stavanger, Norway;2. The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway;3. Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA;4. Department of Neurology, The Jacobs Neurological Institute, State University of New York at Buffalo, Buffalo, New York, USA;5. Department of Neurology, Stavanger University Hospital, Stavanger, Norway;6. Institute of Clinical Medicine, University of Bergen, Bergen, Norway;7. Department of Neurology, Haukeland University Hospital, Bergen, Norway;8. Division of Psychiatry, Stavanger University Hospital, Stavanger, Norway |
| Abstract: | Mild cognitive impairment (MCI) may predict future development of dementia in Parkinson's disease (PD). We aimed to examine the extent of subcortical brain atrophy in patients with early PD with and without MCI compared to normal controls (NC). Participating in a population‐based study were 43 early, drug‐naïve PD patients and 41 NC. Eleven patients were classified with MCI (MCI PD) and 32 patients without (non‐MCI PD). Volumetric segmentation of 3D‐T1 weighted brain MRI was performed using FreeSurfer. Groups were compared applying MANCOVA corrected for total intracranial volume, age, and sex. Results showed that left inferior lateral ventricle and third ventricle volumes were significantly larger in MCI PD than in non‐MCI PD and NC. Fourth ventricular size in MCI PD was significantly different from NC and highly correlated with memory performance in MCI PD patients. This suggests that cognitive dysfunction in early PD may be associated with ventricular enlargement. © 2010 Movement Disorder Society |
| Keywords: | Parkinson's disease MRI volumetric MRI MCI (mild cognitive impairment) |