3D GRASE PROPELLER: Improved image acquisition technique for arterial spin labeling perfusion imaging |
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| Authors: | Huan Tan W Scott Hoge Craig A Hamilton Matthias Günther Robert A Kraft |
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| Institution: | 1. School of Biomedical Engineering and Sciences, Virginia‐Tech and Wake Forest University, Winston‐Salem, North Carolina, USA;2. Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts, USA;3. Mediri GmbH, Heidelberg, Germany;4. Fraunhofer MEVIS, Bremen, Germany;5. University Bremen, Bremen, Germany |
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| Abstract: | Arterial spin labeling is a noninvasive technique that can quantitatively measure cerebral blood flow. While traditionally arterial spin labeling employs 2D echo planar imaging or spiral acquisition trajectories, single‐shot 3D gradient echo and spin echo (GRASE) is gaining popularity in arterial spin labeling due to inherent signal‐to‐noise ratio advantage and spatial coverage. However, a major limitation of 3D GRASE is through‐plane blurring caused by T2 decay. A novel technique combining 3D GRASE and a periodically rotated overlapping parallel lines with enhanced reconstruction trajectory (PROPELLER) is presented to minimize through‐plane blurring without sacrificing perfusion sensitivity or increasing total scan time. Full brain perfusion images were acquired at a 3 × 3 × 5 mm3 nominal voxel size with pulsed arterial spin labeling preparation sequence. Data from five healthy subjects was acquired on a GE 1.5T scanner in less than 4 minutes per subject. While showing good agreement in cerebral blood flow quantification with 3D gradient echo and spin echo, 3D GRASE PROPELLER demonstrated reduced through‐plane blurring, improved anatomical details, high repeatability and robustness against motion, making it suitable for routine clinical use. Magn Reson Med, 2011. © 2011 Wiley‐Liss, Inc. |
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| Keywords: | arterial spin labeling PROPELLER 3D GRASE |
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