Rate of decline of ferritin in patients with hemophagocytic lymphohistiocytosis as a prognostic variable for mortality |
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Authors: | Tiffany F Lin MD Laura L Ferlic‐Stark MS Carl E Allen MD PhD Claudia A Kozinetz PhD Kenneth L McClain MD PhD |
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Institution: | Baylor College of Medicine, Department of Pediatrics, Texas Children's Cancer Center/Hematology Service, and Epidemiology Center |
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Abstract: | Hemophagocytic lymphohistiocytosis (HLH) is difficult to diagnose and treat. Highly elevated ferritin is strongly associated with HLH and levels may provide a prognostic marker. A comprehensive review of ferritin data from our patients during treatment was analyzed with respect to mortality. A patient was 17 times more likely to die when percent ferritin decrease was less than 50% as compared to a 96% or greater decrease as indicated with multivariate logistic modeling. Higher maximum ferritin levels in the first 3 weeks also contributed to the odds of death (OR = 5.6; 90% CI = 1.2–24.9). Regular ferritin measurements may be useful predicting outcomes in HLH patients. Pediatr Blood Cancer. 2010;56:154–155. © 2010 Wiley‐Liss, Inc. |
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Keywords: | ferritin hemophagocytic lymphohistiocytosis (HLH) outcome prognosis |
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