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Hollow Polyaniline and Indomethacin Composite Microspheres for Controlled Indomethacin Release |
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| Authors: | Lijuan Zhang Zhiming Zhang Paul A. Kilmartin Jadranka Travas‐Sejdic |
| Affiliation: | 1. Polymer Electronics Research Centre, School of Chemical Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand;2. College of Chemistry and Chemical Engineering, Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education, Ocean University of China, Qingdao 2661002, China;3. MacDiarmid Institute for Advanced Materials and Nanotechnology, Victoria University of Wellington, P.O. Box 600, Wellington 6140, New Zealand |
| Abstract: | Composite hollow microspheres consisting of polyaniline (PANI) and indomethacin (IND) are prepared through a self‐assembly process in a mixed methanol/water solutions. Different volume fractions of methanol to water and different aniline concentrations are investigated to obtain the optimal conditions for the formation of PANI/IND composite hollow microspheres. The morphologies of the PANI/IND composites are characterized, showing the inner hollow center of the microspheres. Spectroscopic characterizations reveal that the synthesized materials have many typical features of chemically synthesized PANI and confirm the presence of IND in the composites. A controlled release of IND is achieved by adjusting the pH value of the buffer solution. |
| Keywords: | controlled drug release polyaniline composite microspheres |