Serotonergic heterotypic sprouting in the unilaterally dopamine-depleted mouse neostriatum |
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| Authors: | Yamazoe I Takeuchi Y Matsushita H Kawano H Sawada T |
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| Affiliation: | Department of Pediatrics, Kyoto Prefectural University of Medicine, Kyoto, Japan. Ichiro.Yamazoe@ma2.seikyou.ne.jp |
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| Abstract: | The effects of unilateral 6-hydroxydopamine (6-OHDA) treatment on striatal serotonin neurons in 12-day-old mice were studied using immunohistochemistry. The unilateral 6-OHDA lesions were evaluated with tyrosine hydroxylase (TH) immunohistochemistry. The majority of the TH-immunoreactive structures disappeared from the substantia nigra and neostriatum on the 6-OHDA lesioned side. However, the density of serotonin fibers was markedly increased throughout the 6-OHDA-depleted neostriatum 1 year later. These results suggest that serotonergic heterotypic sprouting may be permanent. |
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