| 低氧对大白鼠放射性肺损伤的防护作用 |
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| 引用本文： | 张大昕,刘元华,杨雁飞,李敬君,白云露.低氧对大白鼠放射性肺损伤的防护作用[J].中华放射肿瘤学杂志,1995(3). |
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| 作者姓名： | 张大昕 刘元华 杨雁飞 李敬君 白云露 |
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| 作者单位： | 黑龙江省肿瘤医院 |
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| 摘 要： | 观察低氧对大白鼠肺放射损伤的防护效果。动物雌雄等比例分成单照组、低氧对照组和空白对照组。照射剂量为４０５０ｃＧｙ／９次／３周，照射结束后第７和第１２０天测肺组织脂质过氧化物中间产物丙二醛含量并进行超微结构观察。结果，３组丙二醛含量均值分别为１１０．９１ｎｍｏｌ／ｇ，８２．９６／ｎｍｏｌ／ｇ，８０．４ｎｍｏｌ／ｇ，经Ｆ检验３组间有显著差异，两两比较单照组与低氧组有显著差异。形态学上、毛细血管和肺泡Ⅱ型细胞损伤程度，早、晚期低氧组均较单照组轻
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| 关 键 词： | 放射损伤 肺 低氧 防护 |
RADIOPROTECTIVE EFFECT OF HYPOXIA IN RAT LUNG |
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| Zhang Da Xin,Liu Yuanhua,Yang Yanfei,et al..RADIOPROTECTIVE EFFECT OF HYPOXIA IN RAT LUNG[J].Chinese Journal of Radiation Oncology,1995(3). |
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| Authors: | Zhang Da Xin Liu Yuanhua Yang Yanfei |
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| Institution: | Zhang Da Xin,Liu Yuanhua,Yang Yanfei,et al. Heilongjiang Provincial Cancer,Harbin,150040 |
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| Abstract: | Male and female WKA rats were equally divided into three groups: Irradiation group; hypoxia radiation group; control group. Radiation dose was 4050cGy/9 times, 3 weeks. Malonic aldehyde (intermediate products of lipid-peroxide) were assayed at the seventh day after irradiation. Ultrastructure of lung were observed at day 7 and 120. The mean value of malonic aldehyde of three groups were 110. 91, 82. 96 and 80.4nmol/g, respectively. There was significant difference between three groups (F=4 133, P<0 05). The damage of the capillary and the type pneumocyte in hypoxy-radiation group was less severe than those in irradiation group. |
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| Keywords: | Radioprotective effect Hypoxia |
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