Stability of MRI metrics in the advanced research core of the NCAA-DoD concussion assessment,research and education (CARE) consortium |
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Authors: | Andrew S. Nencka Timothy B. Meier Yang Wang L. Tugan Muftuler Yu-Chien Wu Andrew J. Saykin Jaroslaw Harezlak M. Alison Brooks Christopher C. Giza John Difiori Kevin M. Guskiewicz Jason P. Mihalik Stephen M. LaConte Stefan M. Duma Steven Broglio Thomas McAllister Michael A. McCrea Kevin M. Koch |
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Affiliation: | 1.Department of Radiology,Medical College of Wisconsin,Milwaukee,USA;2.Department of Neurosurgery,Medical College of Wisconsin,Milwaukee,USA;3.Department of Radiology and Imaging Science,Indiana University School of Medicine,Indianapolis,USA;4.Department of Epidemiology and Biostatistics,Indiana University,Bloomington,USA;5.Department of Orthopedics and Rehabilitation,University of Wisconsin School of Medicine and Public Health,Madison,USA;6.Department of Pediatrics and Neurosurgery, UCLA Steve Tisch BrainSPORT Program,University of California Los Angeles,Los Angeles,USA;7.Department of Orthopedics,University of California Los Angeles,Los Angeles,USA;8.Department of Exercise and Sport Science,University of North Carolina,Chapel Hill,USA;9.Virginia Tech Carilon Research Institute,Virginia Tech,Blacksburg,USA;10.Institute for Critical Technology and Applied Science,Virginia Tech,Blacksburg,USA;11.Department of Kinesiology,University of Michigan,Ann Arbor,USA;12.Department of Psychiatry,Indiana University School of Medicine,Bloomington,USA |
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Abstract: | The NCAA-DoD Concussion Assessment, Research, and Education (CARE) consortium is performing a large-scale, comprehensive study of sport related concussions in college student-athletes and military service academy cadets. The CARE “Advanced Research Core” (ARC), is focused on executing a cutting-edge investigative protocol on a subset of the overall CARE athlete population. Here, we present the details of the CARE ARC MRI acquisition and processing protocol along with preliminary analyzes of within-subject, between-site, and between-subject stability across a variety of MRI biomarkers. Two experimental datasets were utilized for this analysis. First, two “human phantom” subjects were imaged multiple times at each of the four CARE ARC imaging sites, which utilize equipment from two imaging vendors. Additionally, a control cohort of healthy athletes participating in non-contact sports were enrolled in the study at each CARE ARC site and imaged at four time points. Multiple morphological image contrasts were acquired in each MRI exam; along with quantitative diffusion, functional, perfusion, and relaxometry imaging metrics. As expected, the imaging markers were found to have varying levels of stability throughout the brain. Importantly, between-subject variance was generally found to be greater than within-subject and between-site variance. These results lend support to the expectation that cross-site and cross-vendor advanced quantitative MRI metrics can be utilized to improve analytic power in assessing sensitive neurological variations; such as those effects hypothesized to occur in sports-related-concussion. This stability analysis provides a crucial foundation for further work utilizing this expansive dataset, which will ultimately be freely available through the Federal Interagency Traumatic Brain Injury Research Informatics System. |
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