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| 厚朴对实验大鼠的胃动力影响 | |
| 引用本文： | 王贺玲,白菡,王学清,李岩.厚朴对实验大鼠的胃动力影响[J].实用药物与临床,2007,10(2):65-66. |
| 作者姓名： | 王贺玲 白菡 王学清 李岩 |
| 作者单位： | 1. 沈阳市第一人民医院消化内科,沈阳,110041 2. 中国医科大学附属盛京医院感染科,沈阳,110004 3. 中国医科大学附属盛京医院消化内科,沈阳,110004 |
| 摘 要： | 目的探讨厚朴对胃动力障碍的改善作用。方法给大鼠腹腔注射盐酸左旋精氨酸(L-Arg)制成胃动力异常模型,同时给予厚朴灌胃观察其对L-Arg所致大鼠胃动力、胃动素异常的改善作用。结果给大鼠腹腔注射L-Arg造成胃动力减缓、血清胃动素减少,厚朴能有效抑制L-Arg引起的大鼠胃动力下降(P<0.05)和胃动素的下降(P<0.05)。结论厚朴对L-Arg所致大鼠胃肠动力障碍有明显的改善作用,其机制与提高血浆胃动素水平有关。 |
| 关 键 词： | 厚朴 胃动力障碍 胃动素 |
| 收稿时间： | 2006-12-12 |
| 修稿时间： | 2006年12月12 |
Experimental studies of effect of cotex magnolia officinal on improving rat's gastrointestinal motility |
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| WANG He- ling, BAI-han, WANG Xue-qing,et al..Experimental studies of effect of cotex magnolia officinal on improving rat''''s gastrointestinal motility[J].Practical Pharmacy and Clinical Remedies,2007,10(2):65-66. | |
| Authors: | WANG He- ling BAI-han WANG Xue-qing |
| Institution: | WANG He- ling, BAI-han, WANG Xue-qing, et al. |
| Abstract: | Objective To study the effect of cotex magnolia officinal on improving gastrointestinal motility.Methods The rats were injected into abdominal cavity by L-Arginine(L-Arg),and cotex magnolia officinal were put into the stomach of rats,the effect of it on gastrointestinal motility and motilin(MTL) was observed.Results L-Arg made the gastric emptying of rats slowly and the decline of MTL in blood plasma;cotex magnolia officinal could inhibit the effects of L-Arg on decreasing gastrointestinal motility(P<0.05) and the plasma motilin(MTL) in rats(P<0.05).Conclusion cotex magnolia officinal can improve the obstacle of the rats's gastrointestinal motility made by L-Arg.The mechanism is related with improving the level of MTL in blood plasma. |
| Keywords: | Cotex magnolia officinal Gastrointestinal motility Motilin(MTL) |
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