| 含RGD修饰的丹参酮ⅡA多级靶向纳米粒的制备及工艺优化 |
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| 引用本文： | 王 炎 宋大迁 王 青 等. 含RGD修饰的丹参酮ⅡA多级靶向纳米粒的制备及工艺优化[J]. 中国医药科学, 2014, 0(3): 9-11,17 |
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| 作者姓名： | 王 炎 宋大迁 王 青 等 |
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| 作者单位： | 上海中医药大学附属龙华医院中医肿瘤研究所;上海中医药大学附属曙光医院肿瘤科;上海中医药大学中西医结合肿瘤介入研究所; |
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| 基金项目： | 国家自然科学基金资助项目(81001594);上海市科学技术委员会科研计划项目(114119a9500);上海市科学技术委员会科研计划项目(11nm0504500);上海市卫生局青年科研项目(2009Y091) |
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| 摘 要： | 目的：探讨丹参酮ⅡA多级靶向纳米粒的制备及其工艺优化。方法采用乳化溶剂蒸发法制备丹参酮ⅡA多级靶向纳米粒；考察单因素在纳米粒制备过程中的影响，包括TSⅡA载药纳米粒中的药物浓度、乳化剂浓度、有机相/外水相、超声时间和强度等的改变；并通过正交设计优化TSⅡA多级靶向纳米粒的制备工艺。结果本实验成功制备了含RGD修饰的丹参酮ⅡA多级靶向纳米粒，优选工艺参数为：药物浓度1mg/mL，载体材料浓度20mg/mL，有机相/外水相为1∶10，超声强度和时间分别为200W，20×5s。结论此丹参酮ⅡA多级靶向纳米粒的制备工艺切实可行。所制备的TNP包封率和载药量较高，为丹参酮ⅡA的临床应用提供了更广阔的前景。
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| 关 键 词： | 丹参酮ⅡA 载药纳米粒 RGD 肿瘤靶向 |
Preparation and optimization of TSIIA-loaded mPEG-PLGA-PLL-cRGD nanoparticles |
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| WANG Yan,SONG Daqian,WANG Qing,FENG Yuanyuan,XU Ling,FAN Zhongze,LI Qi. Preparation and optimization of TSIIA-loaded mPEG-PLGA-PLL-cRGD nanoparticles[J]. China Medicine and Pharmacy, 2014, 0(3): 9-11,17 |
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| Authors: | WANG Yan SONG Daqian WANG Qing FENG Yuanyuan XU Ling FAN Zhongze LI Qi |
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| Affiliation: | 1.Tumor Institute of Traditional Chinese Medicine, Longhua Hospital, Shanghai University of TCM, Shanghai 200032, China;2. Department Of Medical Oncology, Shuguang Hospital,Shanghai University of TCM, Shanghai 201203, China; 3.Department of Cancer Institute of Integrative Medicine, Shanghai University of TCM, Shanghai 200062, China) |
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| Abstract: | Objective To study the targeting efficacy of Tanshinone Ⅱ A（TSⅡA） nanoparticles（TNP）. Methods TNP was prepared by a oil-in-water （O/W） emulsion/solvent evaporation method and orthogonal design for optimization of formulation and technology. Results The optimum formula and preparation method NP were： TSIIA 1mg/Ml, mPEG-PLGA-PLL 20mg/mL, O/W 1 ︰ 10, with sonicate time of 20×5s and sonicate intensity of 200W. Conclusion The TNP has high entrapment efficiency and drug loading, which provides an extensive prospect for clinical application of TSⅡA. |
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| Keywords: | TanshinoneⅡA Nanoparticles cRGD Tumor target |
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