功能性便秘动力学改变与情志因素的相关性

目的:分析功能性便秘(functional constipation,FC)肛肠动力学与患者生活质量及情志因素相关性.方法:患者进行肛肠动力学指标观察分析,采用生命质量调查问卷、精神心理状态评定量表问卷调查,进行动力学指标和情志因素相关性分析.结果:患者组生活质量所有8个维度的评分均低于健康对照组,存在明显的焦虑、抑郁情绪.焦虑、抑郁积分与生活质量负相关;肛肠动力学和精神心理因素相关(P<0.05),肛管缩榨压及其持续时间与抑郁自评量表(selfrating depression scale,SDS)、焦虑自评量表(selfrating anxiety scale,SAS)呈负相关;初始感觉阈值、排便感觉阈值和最大耐受容量与SAS、SDS呈正相关.结论:便秘显著损害患者的生存质量,易合并有焦虑、抑郁等情志因素的异常.焦虑、抑郁和生存质量相关,肛肠动力学和精神心理因素相关.

Correlation of anorectal motility with anxiety and depression in patients with functional constipation

AIM: To investigate the correlation of anorectal motility with anxiety and depression in patients with functional constipation (FC). METHODS: Anorectal manometry was used to examine the changes in anorectal function. The quality of life affected by constipation was evaluated using the 36-item short form health survey scale. Anxiety and depression were assessed using the Zung self-rating anxiety and depression scales. RESULTS: The quality of life scores in FC patients were significantly lower than those in healthy controls. The quality of life scores were negatively correlated with anxiety and depression in FC patients. Anorectal motility parameters were significantly associated with anxiety and depression. Anal squeeze pressure and anal squeeze pressure duration were negatively correlated with anxiety and depression, while anal resting pressure, first sensation volume, defecating sensation volume, and maximum tolerable volume were positively correlated with anxiety and depression. CONCLUSION: FC patients tend to suffer from anxiety and depression. The quality of life in FC patients negatively correlates with anxiety and depression. Anorectal motility parameters are closely associated with anxiety and depression in FC patients.