感冒胶囊提取工艺的研究

目的：确定感冒胶囊(黄连、麻黄等)中黄连、麻黄的提取工艺。方法：以盐酸小檗碱浸出量为评价指标，对黄连单提与黄连、麻黄混提进行比较；采用正交试验法，分别以盐酸小檗碱、麻黄碱的浸出量为评价指标，对黄连、麻黄的水提工艺进行优选。结果：黄连单独提取比黄连、麻黄混合提取效果好。黄连水提的最佳工艺条件为：加水浸泡0．5h，提取3次，加水量分别为12倍、10倍、10倍量，提取时间分别为1．5，1．0，1．0h。麻黄水提的最佳工艺条件为：加水浸泡0．5h，提取3次，加水量分别为10倍、8倍、8倍量，提取时间分别为1．5，1．0，1．0h。结论：试验结果为确定该胶囊中黄连、麻黄的提取工艺提供了实验依据。

Study on extraction of Ganmao Capsules

Objective: To study the optimum process of Ganmao Capsules(Rhizoma Coptidis, Herba Ephedrae, etc.). Methods : The extraction of Rhizoma Coptidis and Herba Ephedrae compared with Rhizoma Coptidis according to amount of berberine. The orthogonal design was used to select the optimum extraction according to amounts of berberine and ephedrine. Results : The extraction of Rhizoma Coptidis was better than that mixed Rhizoma Coptidis and Herba Ephedrae. Taking water as solvent, Rhizoma Coptidis was macerated for 0.5h and extracted in sequence three times with 12, 10 and 10 times volume of water extraction time for 1.5h, 1.0h and 1.0h, respectively. And Herba Ephedrae was macerated for 0.5h and extracted in sequence three times with 10, 8 and 8 times volume of water extraction time for 1.5h, 1.0h and 1.0h. Conclusion : The experimental results provided the basis for the ascertainment of extraction process of Rhizoma Coptidis and Herba Ephedrae preparation.