| 盐酸多沙普仑在中国汉族健康人体内的药动学 |
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| 引用本文： | 郭涛,程佳,夏东亚,贾立辉,颜鸣,唐云彪.盐酸多沙普仑在中国汉族健康人体内的药动学[J].中国药物应用与监测,2010,7(2):82-84. |
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| 作者姓名： | 郭涛 程佳 夏东亚 贾立辉 颜鸣 唐云彪 |
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| 作者单位： | 1. 沈阳军区总医院药剂科,辽宁,沈阳,110016
2. 沈阳药科大学药学院,辽宁,沈阳,110016 |
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| 基金项目： | 全军医学科学技术研究"十一五"计划科技攻关课题基金资助 |
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| 摘 要： | 目的：研究盐酸多沙普仑注射液在汉族健康志愿者体内的药代动力学。方法：10名健康志愿者,男女各半,单次静脉滴注盐酸多沙普仑注射液50mg,定时采血,用反相高效液相色谱法测定血药浓度,DAS软件程序计算药动学参数。结果：多沙普仑的体内过程符合二室模型,主要药代动力学参数为Cma（x1.55±0.52）μg·mL^-1,T1/（23.87±2.17）h,Vd/F（1.35±0.96）L·kg^-1,AUC0（-t3.51±1.26）mg·h·L^-1,AUC0-∞（4.06±1.44）mg·h·L^-1。结论：多沙普仑的药动学参数与文献报道基本一致,可作为不同民族人群药动学研究的基础。
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| 关 键 词： | 多沙普仑 高效液相色谱法 药动学 汉族人 |
Pharmacokinetics of doxapram hydrochloride in Chinese Han healthy volunteers |
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| Authors: | GUO Tao CHENG Jia XIA Dong-ya JIA Li-hui YAN Ming TANG Yun-biao |
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| Institution: | GUO Tao1,CHENG Jia2,XIA Dong-ya1,JIA Li-hui1,YAN Ming1,TANG Yun-biao1(1.Department of Pharmacy,The General Hospital of Shenyang Military Region,Shenyang 110016,China,2.School of Pharmacy,Shenyang Pharmaceutical University,China) |
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| Abstract: | Objective:To investigate the pharmacokinetics of doxapram hydrochloride injection in Chinese Han healthy volunteers.Methods:Ten healthy volunteers including 5 males and 5 females were given a single dose of 50 mg doxapram.The concentration of doxapram in plasma was determined by RP-HPLC,and the pharmacokinetic parameters were calculated by DAS software.Results:The plasma concentration-time profile of doxapram was fitted to a two-compartment model.The main pharmacokinetic parameters were as follows:Cmax(1.55... |
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| Keywords: | Doxapram HPLC Pharmacokinetic Chinese Han |
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