新疆墨玉县农村维吾尔族成人慢性肾脏病流行病学调查

目的 探讨在偏远农村维吾尔族开展慢性肾脏病（CKD）流行病调查的方法，及了解新疆塔里木盆地墨玉县农村维吾尔族成人慢性肾脏病的患病率及相关危险因素。 方法 在预调查的基础上采用分层容量随机抽样方法，从墨玉县364个村抽取15个村18岁以上维吾尔族成人1650人，进行问卷调查、慢性肾损伤指标检测和相关危险因素调查。 结果 在资料完整的1552名维吾尔族成人中，白蛋白尿患病率为4.5%（95%CI为4.4～4.6），肾功能下降患病率为1.4%（95%CI为1.4～1.5）。该人群CKD患病率为5.4%（95%CI为5.3～5.5）。多因素Logistic回归提示高血压、年龄为CKD独立危险因素。 结论 获得了在偏远农村维吾尔族聚集地开展CKD调查的经验和方法。墨玉县农村维吾尔族成人CKD患病率为5.4%，知晓率为12.5%，相关危险因素为高血压和年龄。

Epidemiologic study of chronic kidney disease among Uygur adults in rural area of Moyu county in Xinjiang

Objective To explore the method to carry out epidemiological investigation of chronic kidney disease (CKD) in rural area surrounding the Tarim Basin, and to elucidate the prevalence and risk factors associated with CKD among the Uygur adults in Moyu county. Methods A total of 1650 residents (age >18 years) from 15 villages in 3 rural town of Moyu county were randomly selected by using a stratified, multistage sampling. All the residents were interviewed and received physical examination and tested for random spot urine of albumin to creatinine ratio (ACR). Estimated glomerular filtration rate (eGFR) was calculated by modified MDRD equation. eGFR<60 ml&#8226;min-1&#8226;(1.73 m2)-1 was diagnosed as reduced eGFR. The associated factors of CKD were examined. Results Valid data of 1552 subjects were enrolled in the study. After the adjustment of age and gender component, the prevalence of albuminuria and reduced eGFR was 4.5% (95% CI 4.4-4.6) and 1.4% (95% CI 1.4-1.5) respectively. Approximately 5.4% subjects had at least one indicator of kidney damage. Age and hypertension were independently associated with CKD. Conclusions Experience and method of epidemiology investigation of CKD in the rural areas of Uygur are obtained through this study. The prevalence of CKD is 5.4% and the awareness is 12.5% in the Uygur adults of Moyu county. Independent risk factors associated with CKD are hypertension and age.