祛风止痒酊抑菌、抗炎作用研究

目的:观察祛风止痒酊抑菌,抗炎作用。方法:采用体外抗菌及病原菌感染豚鼠皮肤实验,评价祛风止痒酊的抑菌作用;采用二甲苯致小鼠耳廓肿胀与角叉菜胶致大鼠足跖肿胀模型,观察祛风止痒酊的抗炎作用。结果:祛风止痒酊体外对金黄色葡萄球菌、大肠杆菌、绿脓杆菌、表葡菌、变形杆菌、白色念珠菌均有较明显的抑制作用,可不同程度地减轻金葡菌或绿脓杆菌诱发的豚鼠皮肤感染症状;祛风止痒酊可显著抑制二甲苯致小鼠耳廓肿胀和大鼠足跖肿胀并明显减少炎症组织内PGE₂含量。结论:祛风止痒酊具有较好的体内、外抑菌与抗炎作用。

Experimental Study on the Anti-bacteria and Anti-inflammatory effect of Qufeng Zhiyang Tincture

Objective:To observe the anti-bacteria and anti-inflammatory effects of Qufeng Zhiyang(QFZY)Tincture.Methods: The in vitro anti-bacteria and the experimentation of skin infected by pathogenic bacteria were established to appraise the bacteriostatic effect of QFZY Tincture.The mice ear edema caused by xylene and rat's hind paw swelling inflammatory model caused by carrageenan were employed to study the anti-inflammatory effects.Results: QFZY Tincture had strong inhibiting effect on staphylococcus aureus,bacillus coli,pseudomonas aeruginosa,staphylococcus coat,bacillus distortion,candida albicans.It could alleviate symptom of skin infection elicited by staphylococcus aureus or pseudomonas aeruginosa.QFZY Tincture could significantly suppress ear swell induced by xylene in mice,hind paw tumefaction in rat and decrease PGE₂ in inflammatory tissue.Conclusion:QFZY Tincture had preferably anti-bacteria and anti-inflammatory effects.