113例全胚胎冷冻患者首次冻融胚胎移植的临床分析

目的探讨冻融胚胎移植(frozen-thawed embryo transfer,FET)作为首次移植的临床结局,比较其与新鲜胚胎移植的临床妊娠结局。方法回顾性分析珠海市妇幼保健院生殖中心2010年1月至12月接受人类辅助生殖技术(assis-ted reproductive technology,ART)的共902例患者的临床资料。其中,冻融胚胎移植作为首次移植113例,按全胚胎冷冻的原因不同分为5组,即卵巢过度刺激综合征(OHSS)组、孕酮升高组、雌二醇升高组、胚胎发育迟缓组、其他特殊原因组;同期新鲜胚胎移植789例,为对照组。结果 FET组与对照组相比,无论在不孕原因、获卵数、冷冻胚胎数、移植胚胎数、流产率的差异均无显著的差异,而两组患者临床妊娠率(P<0.05)有统计学差异,但FET各组间存在差异。结论不同因素所致FET的临床妊娠结局存在一定差异,新鲜胚胎移植的条件不适宜时,患者是否适合FET应综合各方面情况来加以考虑,以获得最优的ART妊娠结局。

Study of embryo transfer in infertile patients with 113 cases of whole embryo freezing

Objective:To study the frozen-thawed embryo transfer(FET) as the first transplant,compared with the fresh embryo transplant in clinical pregnancy outcome.Methods:A database was analyzed retrospectively which covered 902 ART cycles from January 2010 to December 2010 in reproductive fertility center of ZhuHai Maternal and Children Health Hospital,including 789 fresh embryo transfer cycles and 113 FET cycles.Results:Compared with the control group,the FET group had no significant differences in the terms of the cause of infertility,the abortion rate,the number of oocytes,frozen embryos and transferred embryos.There were also no significant differences between the control group and the FET group in clinical pregnancy outcome,but the differences existed in the FET groups caused by different factors.Conclusions:The FET groups caused by different factors had differences in the clinical pregnancy outcome.Whether the patient was integrated to take FET,all aspects should be considered in order to obtain the optimal ART pregnancy outcome when the fresh embryo transfer was not suitable.