|
|||||
|
|
The Effect of Cilofungin (LY 121019) in Combination with Amphotericin B or Flucytosine Against Candida Species: Die Wirkung von Cilofungin (LY 121019) in Kombination mit Amphotericin B oder Flucytosin auf Candida-Arten |
|
| Authors: | AN Bulo Suzanne F Bradley Carol A Kauffman |
| Institution: | Division of Infectious Diseases, University of Michigan Medical School, Ann Arbor, Michigan, U.S.A.;Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, U.S.A.;Veterans Administration Medical Center, University of Michigan Medical School, Ann Arbor, Michigan, U.S.A. |
| Abstract: | Cilofungin was combined with amphotericin B or flucytosine to determine if synergistic inhibition or killing occurred against 50 strains of various Candida species. Synergistic inhibition of growth occurred only once with amphotericin B and cilofungin and only 2 times with flucytosine and cilofungin. Synergistic killing occurred in 5 strains with the amphotericin B-cilofungin combination and in 7 strains with the flucytosine-cilofungin combination. Antagonism occurred frequently with both the amphotericin B-cilofungin and the flucytosine-cilofungin combinations. |
| Keywords: | Candida antifungals cilofungin amphotericin B flucytosine synergism Candida Antimykotika Cilofungin Amphotericin B Flucytosin Synergismus |