Positive association between conflicts of interest and reporting of positive results in randomized clinical trials in dentistry

BackgroundThe relationship between industry funding and study results has been explored widely in medicine but not in dentistry. The authors aimed to assess the relationship between conflicts of interest (COIs) and study results.MethodsThe authors assessed all randomized clinical trials (RCTs) published between July 2010 and June 2012 in the 10 dental journals with the highest impact factors in dentistry. The authors used three definitions of COI and explored their associations with positive study results.ResultsDepending on the definition of COI, the odds ratio for reporting positive results varied between 2.40 (95 percent confidence interval CI, 1.16–5.13) and 9.19 (95 percent CI, 1.71–170.64). The authors found no association between positive study results and journal of publication or area of practice.ConclusionsRCTs in which authors have some type of COI are more likely to have results that support the intervention being assessed.Practical ImplicationsWhen reviewing the results of RCTs, clinicians need to be aware of the association between reporting positive study results and the type of COI disclosure and be even more careful when critically appraising and applying their results.