| Abstract: | Nocardia is a ubiquitous microorganism related to pyogranulomatousinfection, which is difficult to treat in humans and animals. The occurrence of thedisease is on the rise in many countries due to an increase in immunosuppressivediseases and treatments. This report of cases from Brazil presents the genotypiccharacterization and the antimicrobial susceptibility pattern using thedisk-diffusion method and inhibitory minimal concentration with E-test® strips. Insummary, this report focuses on infections in young adult men, of which three caseswere cutaneous, two pulmonary, one neurological and one systemic. The pulmonary,neurological and systemic cases were attributed to immunosuppressive diseases ortreatments. Sequencing analysis of the 16S rRNA segments (1491 bp) identified fourisolates of Nocardia farcinica, two isolates of Nocardianova and one isolate of Nocardia asiatica. N.farcinica was involved in two cutaneous, one systemic and other pulmonarycases; N. nova was involved in one neurological and one pulmonarycase; and Nocardia asiatica in one cutaneous case. Thedisk-diffusion antimicrobial susceptibility test showed that the most effectiveantimicrobials were amikacin (100%), amoxicillin/clavulanate (100%), cephalexin(100%) and ceftiofur (100%), while isolates had presented most resistance togentamicin (43%), sulfamethoxazole/trimethoprim (43%) and ampicillin (29%). However,on the inhibitory minimal concentration test (MIC test), only one of the fourisolates of Nocardia farcinica was resistant tosulfamethoxazole/trimethoprim. |
