Alterations of serum antioxidant trace elements (Se,Zn and Cu) status in patients with cutaneous leishmaniasis |
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| Affiliation: | 1. Laboratory of Biomedicine & Department of Hemopathic Tumor of Mongolian Medicine, The Affiliated Hospital of Inner Mongolia University for the Nationalities, Neimenggu Tongliao, PR China;2. Tianjin Key Lab of Molecular Nuclear Medicine, Institute of Radiation Medicine of Chinese Academy of Medical Science and Peking Union Medical College, Tianjin, PR China;3. Department of Human Anatomy, The Medical School of Inner Mongolia University for the Nationalities, Neimenggu Tongliao, PR China;1. Northeast Institute of Geography and Agroecology, Chinese Academy of Sciences, Changchun 130102, Jilin, PR China;2. College of Animal Science and Technology, Jilin Agricultural University, Changchun 130118, Jilin, PR China;1. Laboratoire Matériaux-Molécules et Applications, IPEST, University of Carthage, B.P. 51, 2070 La Marsa, Tunisia;2. University Institute of Tropical Diseases and Public Health, University of La Laguna, Avda Francisco Sanchez s/n, Campus de Anchieta, 38271 La Laguna, Tenerife, Canary Islands, Spain;3. Centre for Integrative Physiology, University of Edinburgh, Scotland, UK;4. Laboratoire d’Ecologie et de Technologie Microbienne, INSAT, University of Carthage, Centre Urbain Nord, B.P. 676, 1080 Tunis Cedex, Tunisia;1. School of Pharmacy, Gold Coast Campus, Griffith University, Queensland, Australia;2. School of Medical Science, Gold Coast Campus, Griffith University, Queensland, Australia;3. Griffith Health Executive, Gold Coast campus, Griffith University, Queensland, Australia |
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| Abstract: | ObjectiveTo assess the serum antioxidant trace elements selenium (Se), zinc (Zn) and copper (Cu) in cutaneous leishmaniasis patients.MethodsIn this study, serum Se, Zn and Cu was determined by using atomic absorption spectrometry in patients with cutaneous leishmaniasis (n=95). The values were statistically compared between patients and control group (n=100) using One-way analysis of variance (ANOVA).ResultsOur results showed that there was a significant difference in the values of Se and Zn between two groups (P<0.000 1 and P<0.01, respectively). Meanwhile, no significant difference in level of Cu was observed between patients and healthy subjects (P>0.05). Se and Zn levels were found to be (4.33±1.06) and (70.23±19.12) μg/dL in cutaneous leishmaniasis cases, and these values were found statistically lower compared to the controls (11.10±2.37) and (119.61±26.18) μg/dL, respectively.ConclusionsThe observations that host products are released from stimulated leukocytes and could induce metabolic changes similar to an acute-phase response revealed an endocrine role for the immune system. Characteristic changes in trace-mineral metabolism are an integral part of the acute-phase response. The changes are usually reflected in decreased serum Se and Zn concentrations. |
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| Keywords: | Cutaneous leishmaniasis Antioxidant trace elements Atomic absorption spectroscopy |
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