Molecular characterization of virulent Leptospira interrogans serogroup Icterohaemorrhagiae isolated from Cavia aperea |
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| Institution: | 1. Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Medicina Veterinária Preventiva e Saúde Animal, São Paulo – SP 05508-270, Brazil;2. Unidade de Vigilância em Saúde, Prefeitura do município de São Paulo, SP, Brazil;3. Centro de Desenvolvimento Tecnológico - Biotecnologia Universidade Federal de Pelotas, RS, Brazil;4. Laboratório de Leptospirose Animal - Universidade Estadual de Londrina, PR, Brazil;5. WHO/FAO/OIE and National Leptospirosis Reference Centre, KIT Biomedical Research, Royal Tropical Institute, Amsterdam, The Netherlands;1. Department of Bacteriology I, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan;2. Bacterial Enteric and Emerging Diseases Laboratory, Center for Research, Diagnostics and Vaccine Development, Centers for Disease Control, Taiwan, No. 161 Kun-Yang Street, Taipei, 11561, Taiwan;3. OIE Leptospirosis Reference Laboratory, Veterinary Sciences Division, Agri-Food and Biosciences Institute, Stoney Road, Belfast BT4 3 SD, United Kingdom;4. Department of Biological Sciences, Okinawa Prefectural Institute of Health and Environment, 2085 Ozato, Ozato, Nanjo-shi, Okinawa 901-1202, Japan;5. Division of Bioresources, Hokkaido University Research Center for Zoonosis Control, Kita-20, Nishi-10, Kita-ku, Sapporo, Hokkaido 001-0020, Japan;6. Ikari Corporation, 579 Chibatera-machi, Chuo-ku, Chiba, Chiba 260-0844, Japan;7. Laboratory of Wildlife Biology and Medicine, Graduate School of Veterinary Medicine, Hokkaido University, Kita-18, Nishi-9, Kita-ku, Sapporo, Hokkaido 060-0818, Japan;8. Civil International Corporation, 1-19-4 Imado, Taito-ku, Tokyo 111-0024, Japan;9. Department of Microbiology, Graduate School of Medicine, Hokkaido University, Kita-15, Nishi-7, Kita-ku, Sapporo, Hokkaido 060-8638, Japan;10. Bacteriology Department, National Institute of Hygiene and Epidemiology, Hanoi 10000, Vietnam |
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| Abstract: | Leptospirosis is a worldwide zoonotic infection caused by pathogenic Leptospira. Synanthropic rodents are recognized carriers of leptospires; however, the role of wild rodents in the epidemiology of the disease is still incipient. In this work, we describe Leptospira strain isolated from Cavia aperea (Brazilian guinea pig). The isolated strain was characterized by partial rpoB gene sequencing, variable-number tandem-repeats and histopathological analysis. The strain was identified as Leptospira interrogans, serogroup Icterohaemorrhagiae and caused clinical signs of leptospirosis in the hamster model, attesting to its virulence. In conclusion, these findings could be useful for elucidating the epidemiological role of C. aperea in leptospirosis. |
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