On the trail of empty MHC class-I |
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| Affiliation: | 1. Advanced Material Science, Graduate School of Frontier Sciences, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Japan;2. Advanced Operando-Measurement Technology Open Innovation Laboratory (OPERANDO-OIL), National Institute of Advanced Industrial Science and Technology (AIST), The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Japan;3. Institute of Multidisciplinary Research for Advanced Materials (IMRAM), Tohoku University, 2-1-1 Katahira Aoba-ku, Sendai, Miyagi, Japan;4. Bio- and Soft-Materials Group, Research & Utilization Division, Japan Synchrotron Radiation Research Institute, 1-1-1 Kouto Sayo-cho, Sayo-gun, Hyogo, Japan;5. Institute of Materials Structure Science, High Energy Accelerator Research Organization, 1-1 Oho, Tsukuba, Japan;6. Molecular Chemistry, Osaka University, 2-1 Yamada-oka, Osaka, Japan;1. Dept. of Biomedical and Specialty Surgical Sciences, Biochemistry Unit, Via Borsari 46, Università di Ferrara, 44121 Ferrara, Italy;2. Dept. of Life Sciences and Reproduction, Section of Biological Chemistry, Strada Le Grazie, 8, Università di Verona, 37134 Verona, Italy;1. Division of Fish Health Management, Central Institute of Freshwater Aquaculture, Kaushalyaganga, Bhubaneswar 751002, Orissa, India;2. Division of Fish Genetics and Biotechnology, Central Institute of Freshwater Aquaculture, Kaushalyaganga, Bhubaneswar 751002, Orissa, India |
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| Abstract: | Since being proposed nearly 25 years ago that MHC-I molecules free of peptide ligand possess a conformation that is distinct from that of the mature loaded form, considerable research has been conducted in order to isolate and characterise such a species. While some progress has been made in our understanding, many questions still surround the nature and loading of empty MHC-I. However, the necessary tools to address these questions may finally be at hand. |
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