Prognostic implications of ischemia modified albumin in known cases of 86 elderly hypertensive South Asian aged 56–64 years – a hospital based study |
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| Institution: | 1. Aix-Marseille Université, CEREGE, CNRS UM 34, F-13545 Aix-en-Provence, France;2. Helmholtz-Zentrum Dresden-Rossendorf (HZDR), D-01314 Dresden, Germany;3. University of Ljubljana, Department of Geography, 1000 Ljubljana, Slovenia;4. Geologische Bundesanstalt, A-1030 Wien, Austria;1. School of Physics and Optoelectronic Engineering, Nanjing University of Information Science & Technology, Nanjing 210044, China;2. Optics and Photonic Technology Laboratory, Nanjing University of Information Science & Technology, Nanjing 210044, China;3. Department of Applied Physics, Nanjing University of Science and Technology, Nanjing 210094, China;1. Restoration Ecology Group, CSIR-National Botanical Research Institute, Rana Pratap Marg, Lucknow 226001, Uttar Pradesh, India;2. Division of Soil Science, CSIR-Central Institute of Medicinal and Aromatic Plants, Picnic Spot Road, Lucknow 226015, Uttar Pradesh, India;3. Rubber Board Regional Office, Housefed Complex, Dispur, Guwahati 781006, Assam, India;1. Laboratory of Renal Lithiasis Research, Faculty of Sciences, Universitary Institute of Health Sciences Research (IUNICS), University of Balearic Islands, Palma de Mallorca, Spain;2. Hospital de Manacor, IB-Salut, Manacor, Spain |
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| Abstract: | ObjectiveTo study associated ischemia modified albumin in hypertensive participants and to compare the results with normotensive healthy controls.MethodsA total of 86 hypertensive patients and 86 age-sex matched normotensive healthy volunteers were selected for this study. The study was conducted for a period of 3 years from September 2007 to August 2010. Biochemical parameters and other parameters such as smoking habits, systolic and diastolic blood pressure and family history were recorded. Lipid profile, ischemia modified albumin, malondialdehyde and conjugated diene were measured by standard methods and results were compared between patients and controls.ResultsTotal cholesterol, triglycerides, low density lipoprotein cholesterol were significantly higher (P<0.001) in hypertensive subjects when compared to normotensive control. Also, significant differences were seen in high density lipoprotein cholesterol levels between both groups (P<0.001). The index of lipid per oxidation comprising both malondialdehyde and conjugated dienes were significantly higher in hypertensive compared to normotensive controls. Ischemia modified albumin levels were significantly increased among hypertensive compared to normotensive controls (P<0.001).ConclusionsHypertensive patients have increased oxidative stress and are accompanied with rise in ischemia modified albumin. Ischemia modified albumin could be incorporated as a diagnostic test parameter in hypertensive to avoid the future acute coronary complications. |
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| Keywords: | Hypertension Ischemia modified albumin Malondialdehyde Conjugated diene South Asian |
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