Drug Induced Liver Injury: Review with a Focus on Genetic Factors,Tissue Diagnosis,and Treatment Options |
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| Authors: | Tawfik Khoury Ayman Abu Rmeileh Liron Yosha Ariel A. Benson Saleh Daher Meir Mizrahi |
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| Affiliation: | 1.Department of Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, Israel;2.Department of Gastroenterology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel;3.Center for Advanced Endoscopy, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, USA |
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| Abstract: | Drug-induced liver injury (DILI) is a rare but potentially life threatening adverse drug reaction. DILI may mimic any morphologic characteristic of acute or chronic liver disease, and the histopathologic features of DILI may be indistinguishable from those of other causes of liver injury, such as acute viral hepatitis. In this review article, we provide an update on causative agents, clinical features, pathogenesis, diagnosis modalities, and outcomes of DILI. In addition, we review results of recently reported genetic studies and updates on pharmacological and invasive treatments. |
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| Keywords: | DILI Hepatotoxicity Treatment |
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