Effects of combined aerobic and resistance training on the glycolipid metabolism and inflammation levels in type 2 diabetes mellitus

[Purpose] To investigate the effects of combined aerobic and resistance training onglycolipid metabolism and inflammation levels in type 2 diabetes mellitus patients.[Subjects and Methods] Forty-two diabetes patients were randomized to the conventionaltherapy group (n = 20) or intensive therapy group (n =22). The control group contained 20 healthy people. The conventional therapy groupreceived routine drug therapy and diet control, while the intensive therapy groupadditionally underwent combined aerobic and resistance training for 12 weeks. The oralglucose tolerance test and cardiopulmonary exercise testing were performed. Toll-likereceptor 4 and NF-κBp65 protein and mRNA expressions were determined by qPCR and westernblotting. ELISA was used to determine the expression levels of interleukin-18,interleukin-33, pentraxin-related protein 3, and human cartilage glycoprotein 39.[Results] After exercise training, the intensive therapy group had significantly lowerpostprandial blood glucose, postprandial insulin, and glycated hemoglobin level andinsulin resistance index than the conventional therapy group. The intensive therapy grouphad significantly lower toll-like receptor 4 and NF-κBp65 protein and mRNA expressions,and serum interleukin-18 levels but significantly higher serum interleukin-33 levels.[Conclusion] Combined aerobic and resistance training can improve glycolipid metabolismand reduce low-grade inflammation in patients with diabetes mellitus patients.Key words: Type 2 diabetes mellitus, Exercise therapy, Inflammation