Effect of remote ischemic postconditioning in inflammatory changes of the
lung parenchyma of rats submitted to ischemia and reperfusion |
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| Authors: | Rafael Cantero Dorsa José Carlos Dorsa Vieira Pontes Andréia Concei??o Brochado Antoniolli Guilherme Viotto Rodrigues da Silva Ricardo Adala Benfatti Carlos Henrique Marques dos Santos Elenir Rose Cury Pontes José Anderson Souza Goldiano |
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| Institution: | 1. Federal University of Mato Grosso do Sul (UFMS), Campo Grande, MS, Brazil.;2. General Director of the Nucleus of the University Hospital of the Federal University of Mato Grosso do Sul (UFMS), Campo Grande, MS, Brazil.;3. Assistant Professor in Cardiovascular Surgery at the Federal University of Mato Grosso do Sul (UFMS), Campo Grande, MS, Brazil.;4. Specialist in Cardiopulmonary Bypass of the Federal University of Mato Grosso do Sul (UFMS), Campo Grande, MS, Brazil. |
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| Abstract: | ObjectiveTo assess the effects of postconditioning remote in ischemia-reperfusion injury in
rat lungs.MethodsWistar rats (n=24) divided into 3 groups: GA (I/R) n=8, GB (R-Po) n=8, CG
(control) n=8, underwent ischemia for 30 minutes artery occlusion abdominal aorta,
followed by reperfusion for 60 minutes. Resected lungs and performed histological
analysis and classification of morphological findings in accordance with the
degree of tissue injury. Statistical analysis of the mean rating of the degree of
tissue injury.ResultsGA (3.6), GB (1.3) and CG (1.0). (GA GB X P<0.05).ConclusionThe remote postconditioning was able to minimize the inflammatory lesion of the
lung parenchyma of rats undergoing ischemia and reperfusion process. |
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| Keywords: | Ischemia Reperfusion Ischemic Postconditioning Lung Injury |
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