Antimalarial potency of the methanol leaf extract of Maerua crassifolia Forssk (Capparaceae) |
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| Affiliation: | 1. Department of Pharmacology, College of Medical Sciences, University of Calabar, Nigeria;2. Department of Microbiology, Human Virology and Biotechnology, National Institute for Pharmaceutical Research and Development (NIPRD), Abuja, Nigeria;3. Department of Pharmacology and Therapeutics, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Nigeria;1. University of Cyprus, Cyprus;2. King''s College London, UK;3. Université Paris-Est, France;4. Curtin University, Digital Ecosystems & Business Intelligence Institute, Center for Stringology & Applications, Australia;1. Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, P.O. Box 71010, Wuhan 430071, PR China;2. Department of Mathematics, Central China Normal University, Wuhan 430079, PR China;1. School of Biosciences and Biotechnology, University of Camerino, via Gentile III da Varano, 62032 Camerino, MC, Italy;2. School of Pharmacy, University of Camerino, via circonvallazione 93/95, 62024 Matelica, MC, Italy;3. School of Veterinary Medical Sciences, University of Camerino, via circonvallazione 93/95, 62024 Matelica, MC, Italy;4. Department of Organic Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, Santiago de Compostela 15782, Spain;5. Department of Chemistry, American University, Washington, DC 20016, USA;1. Department of Biochemistry, University of Ilorin, Ilorin 240001, Nigeria;2. Department of Physiology, University of Ilorin, Ilorin 240001, Nigeria;3. Department of Microbiology, University of Ilorin, Ilorin 240001, Nigeria;4. Department of Chemistry, University of Ilorin, Ilorin 240001, Nigeria;5. Department of Hematology, University of Ilorin, Ilorin 240001, Nigeria;6. Department of Anatomy, University of Ilorin, Ilorin 240001, Nigeria |
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| Abstract: | ObjectiveTo investigate the in vivo antiplasmodial effect of methanol leaf extract of Maerua crassifolia in mice infected with chloroquine sensitive Plasmodium berghei berghei.MethodsThe extract was evaluated for activity against early infection, curative effect against established infection at dose levels of 100, 200 and 400 mg/kg p.o. Chloroquine at 10 mg/kg was used as standard drug.ResultsA dose dependent chemo-suppression of the parasites was obtained at different dose levels of the extract tested with a considerable mean survival time.ConclusionsThe results support continued investigation of components of traditional medicines as potential new antimalarial agents. |
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| Keywords: | Antimalaria Medicinal plant Mice |
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