主动脉脉压及脉压指数与冠状动脉病变严重程度的相关性

目的：探讨主动脉脉压（PP）、脉压指数（PPI）与冠心病严重程度的相关性。方法：选择我院行冠状动脉造影（CAG）患者198例，根据结果分为冠心病及非冠心病组。按年龄分为老年组和非老年组。冠状动脉病变的严重程度用冠状动脉病变Gensini评分系统表示。造影前测定主动脉根部收缩压（SBP）和舒张压（DBP），计算出PP及PPI，两组比较应用t检验；以Pearson相关分析主动脉PP、PPI与冠脉病变程度的相关性；并以冠脉病变程度评分为因变量，其它参数为自变量进行多元逐步回归分析。结果：冠心病组主动脉SBP、DBP、PP及PPI与非冠心病患者相比差异具有显著性（P〈0．05）。老年组主动脉SBP、DBP、PP及PPI与非老年组相比差异具有显著性（P〈0．01）。主动脉PP、PPI与冠脉病变的严重程度密切相关（rPP=0．592、rPPI=0．658，P〈0．01）；回归分析发现，主动脉PPI和年龄进入回归方程，提示主动脉PPI及年龄是冠脉病变的危险因素。结论：主动脉PP及PPI与冠状动脉病变的严重程度密切相关，可预测冠状动脉病变严重程度。

Relevance between aortic pulse pressure and degree of coronary artery disease

Objective： To study the relevance among aortic pulse pressure （PP） , pulse pressure-index （PPI） and degree of coronary artery disease. Methods： One hundred and ninety eight patients undergone coronary angiography （CAG） were divided into coronary heart disease （CHD） and control group （without CHD） according to angiographic finding. All patients were divided into two groups according the age. The Gensini scoring system was used to determine the results of the coronary angiography. The following data were collected ; Invasive intra-aortie systolic and diastolic blood pressure, PP and PPI. All parameters were compared between different groups. To investigate the relation between the level of aortic PP, PPI. and the degree of coronary disease; The relationship among aortic PPI, the Gensini scoring and other factors was further investigated by means of multiple linear regression analysis. Results： The aortic SBP, PP, PPI in CHD group were significantly higher than those of control group, but aortic DBP was markedly lower in CHD group, the same phenomenon were observed in the aged. There were obvious relevance among aortic PP, PPI and the degree of coronary artery disease （rpp=0. 592, rppl=0. 658, P〈0.01 all） ; the age also was the important risk factors. Conclusion： The aortic PP and PPI are the better parameter reflecting to degree of CHD. So they can act as the indexes predicting the risk of cardiovascular disease.