| 人参皂苷Re大鼠体内药物动力学研究 |
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| 引用本文： | 彭缨,王淑君,潘卫三,徐绥绪. 人参皂苷Re大鼠体内药物动力学研究[J]. 沈阳药科大学学报, 2006, 23(4): 197-200 |
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| 作者姓名： | 彭缨 王淑君 潘卫三 徐绥绪 |
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| 作者单位： | 1. 沈阳药科大学,药学院,辽宁,沈阳,110016
2. 沈阳药科大学,中药学院,辽宁,沈阳,110016 |
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| 摘 要： | 目的研究人参皂苷Re在大鼠体内的经时过程并计算药物动力学参数。方法采用HPLC法测定大鼠静脉注射给药后血浆中人参皂苷Re的血药质量浓度,用3P87药动学程序求算其药物动力学参数。结果静脉注射3种不同剂量(20、30、40 mg.kg-1)的人参皂苷Re后,3组大鼠的药物动力学特点成双隔室模型。t1/2(α)分别为6.505、6.817、4.499 min,t1/2(β)分别为28.96、30.49、27.57 min,AUC分别为599.31、1025.65、1415.7 min.mg.L-1。结论主要动力学参数十分相近,且AUC随剂量增加而成比例增加,说明在此剂量范围内Re的消除为线性动力学。
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| 关 键 词： | 人参皂苷Re 药物动力学 高效液相色谱法 |
| 文章编号： | 1006-2858(2006)04-0197-04 |
| 收稿时间： | 2005-04-09 |
| 修稿时间： | 2005-04-09 |
Pharmacokinetics of ginsenoside Re in rat |
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| PENG Ying,WANG Shu-jun,PAN Wei-san,XU Sui-xu. Pharmacokinetics of ginsenoside Re in rat[J]. Journal of Shenyang Pharmaceutical University, 2006, 23(4): 197-200 |
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| Authors: | PENG Ying WANG Shu-jun PAN Wei-san XU Sui-xu |
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| Abstract: | Objective To develop a HPLC method for the determination of ginsenoside Re concentrations in rat plasma samples and to research pharmacokinetics of the concentration-time parameter of ginsenoside Re in rats after iv.Methods The pharmacokinetic characteristics were calculated after iv of 20,30 and(40 mg·kg~(-1)) ginsenoside Re in rats.Results The main parameters t_(1/2(α)) were 6.505,6.817 and(4.499 min) respectively,t_(1/2(β)) were 28.96,30.49 and 27.57 min respectively,The AUC were 599.31,1025.65,1415.7 mg·L~(-1)·min respectively,the main parameters are similar.Conclusions The result that the AUC values are directly relative to the doses indicates that the elimination of ginsenoside Re is linear pharmacokinetics. |
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| Keywords: | ginsenoside Re HPLC pharmacokinetics |
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