不同时间服用厄贝沙坦氢氯噻嗪对高血压患者晨峰血压的影响分析

目的 探讨不同时间服药对高血压患者降压及控制血压晨峰的疗效.方法 对原发性高血压100 例患者随机分成两组：早晨顿服组50 例,晚服用组50 例,使用厄贝沙坦/氢氯噻嗪162.5 mg,治疗8 周.治疗前后门诊随访测量血压、行24 h 动态血压监测,以观察降压疗效及血压晨值的变化.结果 治疗8 周,晨服组与晚服用组服药后比较①治疗后各时点两组的诊室收缩压、白昼收缩压、夜间收缩压均值均较治疗前明显降低,差异均有统计学意义（ 均P〈0.01）.②两组患者治疗后夜间血压平均值比较差异有统计学意义（P〈0.05）.③晚服组晨峰血压降低程度明显高于晨服组（P〈0.05）.结论 厄贝沙坦氢氯噻嗪胶囊无论何时用药均能平稳有效降压,但对晨峰高血压患者采用晚间给药效果更佳,更有利于控制夜间血压水平,有效控制晨峰现象.

Analysing the impact of taking different time he sand jotham hydrochlorothiazide morning peak blood pressure in patients with high blood pressure

Objective To study the different time morning of antihypertensive medication for high blood pressure patients and the control of blood pressure peak of curative effect. Methods 100 cases of primary hypertension patients randomly divided into two groups： the morning meal served group of 50 cases, later taking group of 50 cases, using e bay sand/hydrochlorethiazide 162.5 mg, treatment of 8 weeks. Outpatient follow-up measure blood pressure before and after the treatment, line 24 h ambulatory blood pressure monitoring, to observe the antihypertensive efficacy and morning blood pressure values. Results The treatment of 8 weeks, the morning suits group compared with late after taking medicine group （1） each point clinic systolic blood pressure in both groups after treatment, and the mean systolic blood pressure, systolic blood pressure at night on the day was significantly reduced, the differences were statistically significant （allP〈0.01）, （2） two groups of patients after treatment of nocturnal blood pressure the average comparative difference was statistically significant （P〈0.05）, （3） late morning suit group significantly higher than the peak pressure decline morning suits group （P〈0.05）. Conclusion He sand jotham hydrochlorothiazide capsule whenever drugs axe effective antihypertensive smooth, but for hypertension were treated by late morning peak for better effect, more conducive to control nighttime blood pressure level, effective control of the morning peak.