微生态调节剂联合谷氨酰胺预防老年肠内营养相关性腹泻

目的 探讨微生态调节剂联合谷氨酰胺对老年患者肠内营养相关性腹泻的预防作用.方法 选取行肠内营养治疗患者75例,完全随机分为观察组(42例)和对照组(33例).2组患者均予鼻饲肠内营养混悬液和微生态制剂,前者用量为100 ml/h开始重力滴注,500 ml/d,直至供给全量；2组未静脉滴注抗生素者均选用双歧四联活菌片1.5g/次,3次/d,静脉滴注抗生素者选用乳酸菌素片2.4g/次,3次/d,观察组同时给予谷氨酰胺1.0g/次,3次/d.疗程1周.观察2组患者腹泻发生率和肠内营养达到目标供给量的时间.结果 观察组和对照组患者腹泻发生率分别为9.5％ (4/42)和24.2％ (8/33),差异有统计学意义(x2=5.469,P=0.019).观察组患者肠内营养液达到目标供给量时间为(3.4±1.0)d,小于对照组(4.7±1.5)d,差异有统计学意义(t=4.386,P=0.002).结论 在肠内营养治疗的老年患者中,适量添加微生态调节剂及谷氨酰胺,可明显减少腹泻的发生,利于肠内营养治疗的顺利进行.

Preventive effect of combined microecological and glutamin preparation on enteral nutriton related diarrhea in elderly patients

Objective To study the preventive effect of combined microecological and glutamin preparation on enteral nutriton （EN） related diarrhea in elderly patients. Methods Seventy-five ederly patients with EN were divided into treatment group （n = 42） and control group（ n = 33 ） at random. All patients were fed with nutrion fiber. Treatment group was given with combined microecological and glutamin. Control group was givern microecological. The incidence rate of diarrhea, and the time to reach standard amount were recorded. Results The incidence rate of diarrhea was 9.5% （4/42） in the treatment group and the incidence rate of diarrhea in the control group was 24.2%（8/33） （X2 = 5. 469, P = 0. 019）. The time to reach the standard amount in the treatment group was （3.4 ~ 1.0） d and significantly less than that in the control group [ （4.7 ＋ 1.5 ） d ] （ t = 4. 386, P = 0. 002 ）. Conclusion In the remedial process of elderly patients with EN, it is valuable to add right amount of combined mi- croecologieal and glutamin preparation which can significantly decrease the rate of diarrhea and be of value to EN treatment in elderly patients.