| 孟德尔随机化在常见眼病中的研究进展 |
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| 引用本文： | 张熙然,袁韦辰,李祥瑞,徐菲儿,赵芳坤. 孟德尔随机化在常见眼病中的研究进展[J]. 国际眼科杂志, 2024, 24(5): 784-789 |
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| 作者姓名： | 张熙然 袁韦辰 李祥瑞 徐菲儿 赵芳坤 |
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| 作者单位： | 中国辽宁省沈阳市,中国医科大学;中国辽宁省沈阳市,中国医科大学附属第四医院眼科 |
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| 基金项目： | 辽宁省教育厅2021年度科学研究经费项目(面上项目)(No.LJKZ0773) |
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| 摘 要： | 病因学研究是正确认识疾病发生和流行规律的必要条件，也是临床疾病诊断预防治疗的前提。孟德尔随机化(Mendelian randomization，MR)作为遗传学和流行病学结合的方法，可以在遗传学层面上探究暴露与疾病的因果关系，同时可以避免混杂因素、反向因果的干扰，因此被广泛用于疾病的病因学研究。本文对眼科疾病研究中孟德尔随机化的应用进行综述，并为相关眼病机制研究、干预方法的设计提供更多思路和方法。
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| 关 键 词： | 孟德尔随机化 眼病 病因学研究 因果关系 |
| 收稿时间： | 2023-12-02 |
| 修稿时间： | 2024-03-22 |
Research progress of Mendelian randomization in ocular diseases |
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| Zhang Xiran,Yuan Weichen,Li Xiangrui,Xu Feier,Zhao Fangkun. Research progress of Mendelian randomization in ocular diseases[J]. International Eye Science, 2024, 24(5): 784-789 |
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| Authors: | Zhang Xiran Yuan Weichen Li Xiangrui Xu Feier Zhao Fangkun |
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| Affiliation: | China Medical University, Shenyang 110122, Liaoning Province, China;Department of Ophthalmology, the Fourth Affiliated Hospital of China Medical University, Shenyang 110005, Liaoning Province, China |
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| Abstract: | Etiological research is necessary for understanding the occurrence and epidemiological patterns of diseases, and is also a prerequisite for the diagnosis, prevention and treatment of clinical diseases. Mendelian randomization(MR), a method of research that combines genetics and epidemiology, has the advantage of exploring the causal relationship between exposure and disease genetically as well as avoiding confounding factors and reverse causation. Thus, it has been extensively utilized in the etiological study of diseases. This paper reviews the implementation of MR in the research of ocular diseases and provides ideas and approaches for the investigation of related mechanisms as well as the development of intervention strategies. |
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| Keywords: | Mendelian randomization ocular diseases etiological study causality |
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