| 深低温停循环大鼠脑保护模型的建立 |
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| 引用本文： | 顾群,莫绪明,彭卫,陈凤,何晓敏,丁晋阳. 深低温停循环大鼠脑保护模型的建立[J]. 中华实验外科杂志, 2008, 25(9) |
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| 作者姓名： | 顾群 莫绪明 彭卫 陈凤 何晓敏 丁晋阳 |
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| 作者单位： | 南京医科大学附属南京儿童医院心胸外科,210008 |
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| 基金项目： | 国家自然科学基金，江苏省科教兴卫工程蕈点人才项目 |
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| 摘 要： | 目的 建立一种新的深低温停循环(DHCA)大鼠脑保护模型.方法雄性SD大鼠30只,随机分为3组,即颈动脉阻断DHCA组(A组)、颈内动脉引流DHCA组(B组)和假手术组(C组).于深低温停循环后60 min时监测脑电图变化,停循环60 min后恢复循环并升温.所有大鼠于术后24 h处死,并取脑组织测脑含水量.结果 B组大鼠α波相对功率值明显低于A组(P＜0.01),而且两组大鼠α波相对功率值均明显低于C组(P＜0.01);B组大鼠θ波相对功率值明显低于A组和C组(P＜0.01),而后两组大鼠θ波相对功率差异无统计学意义.脑含水率结果 显示B组大鼠脑含水量高于A组(P＜0.05).结论 颈内动脉引流DHCA模型较颈动脉阻断DHCA模型脑缺血更完全,是一种较为理想的DHCA大鼠脑保护模型.
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| 关 键 词： | 深低温停循环 模型 动物 脑保护 |
Establishment of the brain protection model of deep hypothermic circulatory arrest in rats |
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| Abstract: | Objective To establish the brain protection model of deep hypothermic circulatory arrest(DHCA)in rats.Methods Thirty SD rats were divided randomly into three groups:Carotid occlusion DHCA group(group A);inner carotid shunt DHCA group(group B)and sham-operation group(group C).The changes in electroencephalograph(EEG)were observed 24 h after DHCA.All rats were killed 24 h after DHCA.The brain water content was measured.Results The α and B wave relative powers of EEG in group A were lower and higherthan those in group B respectively(P＜0.05).The brain water content was higher in group B than in group A(P＜0.05).Conclusion Inner carotid shunt DHCA model is a more perfect brain protection one of DHCA. |
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| Keywords: | DHCA Model animal Cerebral protection |
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