| 牛磺酸拮抗铅对原代培养皮层神经元的影响 |
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| 引用本文： | 杨烽,李积胜,杨芳.牛磺酸拮抗铅对原代培养皮层神经元的影响[J].营养学报,2005,27(2):119-121,125. |
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| 作者姓名： | 杨烽 李积胜 杨芳 |
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| 作者单位： | 武警医学院军事预防医学研究所,天津,300162 |
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| 基金项目： | 国家自然科学基金(39870689) |
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| 摘 要： | 目的:研究牛磺酸拮抗铅对原代培养的皮层神经元生长及存活的影响。方法:通过建立新生大鼠皮层神经元原代培养,用不同浓度醋酸铅染毒和给予牛磺酸干预,观察神经细胞的生长和存活情况。结果:终浓度为10-8mol/L的醋酸铅即可抑制神经元突起生长,导致细胞生长活力下降,终浓度为1.6×10-3mol/L的牛磺酸能够抑制这种损害作用,促进神经元生长。结论:牛磺酸能够拮抗铅抑制神经元生长和存活的毒性。
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| 关 键 词： | 牛磺酸 铅 皮层 神经元 |
| 文章编号： | 0512-7955(2005)02-0119-04 |
PROTECTION OF TAURINE AGAINST LEAD TOXICITY IN CULTURES OF CORTEX NEURON |
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| YANG Feng,LI Ji-sheng,YANG Fang.PROTECTION OF TAURINE AGAINST LEAD TOXICITY IN CULTURES OF CORTEX NEURON[J].Acta Nutrimenta Sinica,2005,27(2):119-121,125. |
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| Authors: | YANG Feng LI Ji-sheng YANG Fang |
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| Abstract: | Objective:To study the effect of taurine on protection against lead toxicity in cultured cortex neurons. Methods:Put taurine and different concentrations of lead acetate in cultures of cortex neurons and observe the length of dendites and the growth activity of neurons. Results:At the concentration of 10-8 mol/l lead acetate the growth of cultured cortex neurons were decreased and even the cells died. Taurine at the concentration of 1.6×10-3 mol/L could protect against lead toxicity and promote neuron to grow. Conclusion:Taurine can protect from lead acetate toxicity in cultured cortex neurons. |
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| Keywords: | taurine lead cortex neuron |
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