胸部开放伤后海水浸泡对实验犬血浆渗透压及电解质平衡的影响

探讨胸部开谚伤后海水浸泡对实验犬血浆渗透压和电解质平衡的影响。方法：实验动物致伤后随机分对照组（ｎ＝１０）、海水浸泡组（ｎ＝１０）和生理盐水或生理盐水中，于致伤前及入水１５、３０、４５分钟及１、２、３和４小时取血测定血浆渗透压、血钠、血钾、血氯，同时监测血流动力学变化。结果：海水浸泡组动物有严重的电解质紊乱和血液高渗状态，表现为高渗综合征、高钠血症和高氯血症，而对照组和生理盐水浸泡组致伤前后无明显

Effect of seawater immersion on serum osmotic pressure and electrolyte balance in dogs after open chest injury

Objective:To evaluate the effect of seawater immersion on serum osmotic pressure and electrolyte balance after chest trauma.Methods:A canine model of right open pneumothorax was established.25 health dogs were divided into three groups.Control group ( n =10)was subjected to simple chest trauma,seawater immersion group( n =10) had seawater immersion after chest trauma,and normal saline solution group ( n =5) was immersed into normal saline solution after chest injury.Blood samples were obtained at different time intervals to determine serum osmotic pressure and electrolytes.The hemodynamic changes were also recorded.Results:Posttrauma mortality was much higher in seawater immersion group than that in control group and normal saline solution group.One of the most important causes of death was hypernatremia and high osmotality.In seawater immersion group,the major serum electrolyte imbalance was hypernatremia and hyperchloremia,and hypernatremia resulted in high osmotic pressure.The mean survival time in seawater immersion group was 45 minutes,while in control group and normal saline solution group were more than 4 hours.Conclusions:Seawater immersion after chest trauma appears to be associated with severe electrolyte imbalance as well as high osmotic pressure.These may be the risk factors leading to fatal outcome.