复方甘草酸苷对慢性乙型肝炎患者肝纤维化指标及细胞因子的影响

目的:观察复方甘草酸苷对慢性乙型肝炎患者肝纤维化指标及细胞因子的影响。方法:84例慢性乙型肝炎患者随机分为对照组(常规保肝)和治疗组(常规保肝+复方甘草酸苷),治疗前、后采用酶联免疫吸附双抗体夹心法和放射免疫分析法测定血清转化生长因子-β1(TGF-β1)、肿瘤坏死因子-α(TNF-α)和玻璃酸(HA)、Ⅳ型胶原(Ⅳ-C)、层粘蛋白(LN)水平;20例健康人血清作为正常对照组。结果:慢性乙型肝炎患者血清HA、Ⅳ-C、LN、TGF-β1、TNF-α水平较正常对照组显著升高(P<0.01);治疗3mo后,治疗组的HA、Ⅳ-C、TGF-β1、TNF-α水平较治疗前及对照组治疗后均有显著降低(P<0.01或P<0.05)。结论:复方甘草酸苷可影响慢性乙型肝炎患者的细胞因子,从而发挥抗肝纤维化作用。

Influence of Compound Glycyrrhizin on Hepatic Fibrosis Indices and Cytokines in Patients with Chronic Hepatitis B

OBJECTIVE:To study the influence of compound glycyrrhizin on hepatic fibrosis indices and cytokines in patients with chronic hepatitis B(CHB).METHODS:84 patients with CHB were randomly divided into the treatment group(conventional liver protection+compound glycyrrhizin tablet) and control group(conventional liver protection).The serum levels of transforming growth factor-β1(TGF-β1),tumor necrosis factor-α(TNF-α),hyaluronic acid(HA),collagen type Ⅳ(C-Ⅳ) and laminin(LN) in those patients were measured by specific-ELISA and RIA before and after treatment.The serum levels in 20 healthy subjects were used as normal controls.RESULTS:The serum levels of HA,Ⅳ-C,LN,TGF-β1,TNF-α in patients with CHB were significantly higher than those in healthy subjects(P<0.01).3 months after treatment,the serum levels of HA,Ⅳ-C,TGF-β1,TNF-α and LN in treatment group were significantly lower than before and those in control group after treatment(P<0.01,P<0.05).CONCLUSIONS:Compound glycyrrhizin can influence the levels of cytokines in patient with CHB and therefore have anti-fibrosis effect on liver.