| 肝癌与HBV感染的关系 |
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| 引用本文： | 肖芙蓉,贾杰. 肝癌与HBV感染的关系[J]. 中国热带医学, 2004, 4(5): 803-804 |
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| 作者姓名： | 肖芙蓉 贾杰 |
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| 作者单位： | 海南省人民医院感染内科,海南,海口,570311 |
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| 摘 要： | 目的 探讨肝癌与HBV感染的关系。 方法 对 771例原发性肝癌病人及同期 794例其他消化道恶性肿瘤病人的血清HBV标记进行回顾性对比分析。 结果 发现肝癌组HBV -M阳性 72 6例 ( 94.16% ) ,非肝癌组HBV -M阳性 13 8例 ( 17.3 8% ) ,有显著差异 (P <0 .0 1)。HBV模式中 ,肝癌组HBV -M以“小三阳”( 1-4 -5 )为主 ,占全部肝癌病人的 67% ( 5 17/771) ,明显高于非肝癌组“小三阳”的 13 .5 1% ( 10 7/794)。 结论 原发性肝癌的发生与HBV有着非常密切的关系 ,而HBV与肝细胞的整合及不同的HBV基因型可能是其发生癌变的重要病理生理学基础。
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| 关 键 词： | 原发性肝癌 HBV感染 “小三阳” 阳性 病人 回顾性 HBV基因型 结论 整合 模式 |
| 文章编号： | 1009-9727(2004)05-803-02 |
The correlation between primary hepatic carcinoma and HBV infection |
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| XIAO Fu-rong,JIA Jie.. The correlation between primary hepatic carcinoma and HBV infection[J]. China Tropical Medicine, 2004, 4(5): 803-804 |
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| Authors: | XIAO Fu-rong JIA Jie. |
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| Abstract: | Objective To explore the correlation between primary hepatic carcinoma(HCC) and HBV infection. Methods we HBV sero-markers in 771 patients with HCC and 794 patients with other gastroenterol malignant tumour were analyzed retrospectively. Results The results showed the positive rate of HBV M was 94.16% in HCC group(726/771) and 17.38% in other gastroenterol malignant tumour(138/794) (P<0.01). In HBV M modes, mode 1-4-5 was 67%(517/771) which is main mode in HCC group and 13.51%(107/98) in non HCC group. Conclusion The results suggested that there is closely correlation between HCC and HBV infection. The integration of HBV DNA into the host liver cells and different HBV genotypes may be important factors in the pathogenesis of HCC. |
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| Keywords: | Primary hepatic carcinoma(HCC) Sero-markers of hepatitis B( HBVM) Hepatitis B virus(HBV) Gastroenterol malignant tumour Integration HBV genotypes |
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