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Serum interferon inhibitor declines in patients with HIV-1 infection after a change in antiretroviral therapy |
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| Authors: | Chadha Kailash C Schwartz Stanley A Nair Madhavan P N Demeter Lisa R Hewitt Ross G |
| Affiliation: | a Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, New York, USAb Department of Medicine, Division of Allergy, Immunology and Rheumatology, Buffalo General Hospital, Buffalo, New York, USAc Division of Infectious Diseases, University of Rochester, Rochester, New York, USAd Division of Infectious Diseases, State University of New York, New York, USA |
| Abstract: | An inhibitor of interferon antiviral activity, which is absent in healthy HIV-seronegative persons, was detected in the sera of all 29 HIV-seropositive study participants. The relationship of the level of interferon inhibitor to CD4 count and HIV-RNA copy number was statistically significant in distinct models. Levels of interferon inhibitor declined by an average of 41-60% in patients who underwent a change in anti-retroviral therapy. Interferon inhibitor levels appear to decline as CD4 cell count rises and HIV-RNA levels fall. This suggests that interferon inhibitor may have a significant role in the host immune response to HIV infection. |
| Keywords: | Serum interferon levels Serum interferon inhibitor HIV-infection Antiretroviral therapy HIV-RNA levels |
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