TP53 mutations in ovarian carcinomas from sporadic cases and carriers of two distinct BRCA1 founder mutations; relation to age at diagnosis and survival |
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| Authors: | Pedro Kringen Yun Wang Vanessa Dumeaux Jahn M Nesland Gunnar Kristensen Anne-Lise Borresen-Dale Anne Dorum |
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| Affiliation: | (1) Department of Genetics, The Norwegian Radium Hospital, 0310 Montebello, Oslo, Norway;(2) Department of Gynecologic Oncology, The Norwegian Radium Hospital, 0310 Montebello, Oslo, Norway;(3) University of Oslo, The Norwegian Radium Hospital, 0310 Montebello, Oslo, Norway;(4) Department of Pathology, The Norwegian Radium Hospital, 0310 Montebello, Oslo, Norway;(5) Institute of Community Medicine, University of Troms?, Troms? |
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| Abstract: | Background Ovarian carcinomas from 30 BRCA1 germ-line carriers of two distinct high penetrant founder mutations, 20 carrying the 1675delA and 10 the 1135insA, and 100 sporadic cases were characterized for somatic mutations in the TP53 gene. We analyzed differences in relation to BRCA1 germline status, TP53 status, survival and age at diagnosis, as previous studies have not been conclusive. |
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