E-selectin A561C and G98T polymorphisms influence susceptibility and course of multiple sclerosis |
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| Authors: | Galimberti Daniela Fenoglio Chiara Clerici Raffaella Comi Cristoforo De Riz Milena Rottoli Mariarosa Piccio Laura Ronzoni Marco Venturelli Eliana Monaco Francesco Poloni Marco Bresolin Nereo Scarpini Elio |
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| Affiliation: | Department of Neurological Sciences, "Dino Ferrari" Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Via F. Sforza, 35, 20122, Milan, Italy. daniela.galimbert@unimi.it |
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| Abstract: | Three hundred seven patients with MS and 300 controls were genotyped for G98T and A561C SNPs in the E-selectin gene, and genetic data were correlated with the course of the disease. The frequency of the T/T genotype of the G98T SNP was significantly increased in RR-MS patients compared with controls, while was absent in PP-MS. The frequency of the A561C SNP was significantly decreased in SP-MS compared with benign RR-MS. The T/T genotype of the G98T SNP is likely to confer an increased risk to develop MS. The A561C polymorphism seems to act as protective factor towards the progression to SP-MS. |
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