| 复方黄甘颗粒对肾脏的作用机理研究 |
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| 引用本文： | 侯连兵,杨西晓. 复方黄甘颗粒对肾脏的作用机理研究[J]. 中国药房, 2003, 14(8): 459-461 |
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| 作者姓名： | 侯连兵 杨西晓 |
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| 作者单位： | 第一军医大学南方医院药学部,广州市,510515 |
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| 基金项目： | 国家新药研究基金资助项目( 009-192) |
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| 摘 要： | 目的 :阐明复方黄甘颗粒的作用机理。方法 :用同位素示踪、电磁流量计技术和导尿管集尿法 ,研究复方黄甘颗粒对兔肾血流量、肾小球滤过率和利尿作用。结果 :复方黄甘颗粒能显著增加兔肾血流量、肾小球滤过率 ,具有明显的利尿作用。结论 :复方黄甘颗粒的作用机理是通过增加兔肾血流量和肾小球滤过率 ,以及利尿作用 ,达到降尿素氮和肌酐等肾毒性物质的目的
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| 关 键 词： | 复方黄甘颗粒 作用机理 肾血流量 利尿 |
| 文章编号： | 1001-0408(2003)08-0459-03 |
| 修稿时间： | 2002-09-02 |
Study on Mechanism of Action of Compound Huanggan Granules on the Kidney |
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| HOU Lianbing,YANG Xixiao. Study on Mechanism of Action of Compound Huanggan Granules on the Kidney[J]. China Pharmacy, 2003, 14(8): 459-461 |
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| Authors: | HOU Lianbing YANG Xixiao |
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| Abstract: | OBJECTIVE:To research the mechanism of action of compound Huanggan gr anules(FHG) METHODS:To observe the effect of FHG on the renal blood flow and glomerular filtration rate,and its mechanism of diuresis by means of isotopic tracer,electromagnetic flowmeter and ureter catheterization RESULTS:FHG could significantly increase the renal blood flow and glomerular filtration rate,and enhance the diuresis CONCLUSION:Its diuresis is based on the increase of rena l blood flow and glomerular filtration rate,which results in the decrease of ne phrotoxic substances such as blood urea nitrogen and serum creatinine |
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| Keywords: | compound Huanggan granule mechanism of action renal blood flow diu resis |
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