| 乌司他丁治疗急性坏死性胰腺炎的实验研究 |
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| 引用本文： | 方立峰.乌司他丁治疗急性坏死性胰腺炎的实验研究[J].中国局解手术学杂志,2008,17(4):247-248. |
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| 作者姓名： | 方立峰 |
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| 作者单位： | 郑州市第一人民医院消化科 河南郑州450004 |
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| 摘 要： | 目的探讨乌司他丁治疗急性坏死性胰腺炎的作用，为临床治疗急性坏死性胰腺炎提供参考依据。方法健康的SD大鼠60只，雌雄各半，随机分为假手术组（A组）、未处理组（B组）和急性坏死性胰腺炎乌司他丁治疗组（C组），每组20只。三组动物模型建立后分别于1h,6h、10h从下腔静脉抽血1mL。10h时后处死大鼠，比较各组不同时间血清淀粉酶（AMY）、肿瘤坏死因子（TNF—d）及病理组织学的变化。结果C组分别与A、B组比较，血清AMY、TNF-α及病理组织学方面均有显著性差异。结论乌司他丁能有效地抑制胰酶和细胞因子的分泌、释放，可显著改善急性坏死性胰腺炎的预后。
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| 关 键 词： | 急性坏死性胰腺炎 乌司他丁 动物模型 |
Laboratory research of ulinnastatin used in acute necrotic pancreatitis |
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| FANG Li-feng.Laboratory research of ulinnastatin used in acute necrotic pancreatitis[J].Journal of Regional Anatomy and Operative Surgery,2008,17(4):247-248. |
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| Authors: | FANG Li-feng |
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| Institution: | FANG Li-feng (Department of Gastroenterology, the 1 st People＇ s Hospital of Zhengzhou, Zhengzhou Henan 450004, China) |
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| Abstract: | Objective To explore the treatment of ulinastatin in acute necrotic pancreatitis. Methods Totally 60 healthy Sprague- Dawley（ SD ） rats were randomly divided into 3 groups：group A, sham operation ; group B, acute necrotic pancreatitis with no treatment;group C, acute necrotic pancreatitis treated with ulinastation. The changes of AMY ,TNF-et and pathohistology in the postcava blood drew in different time were compared among 3 groups. Results AMY,TNF-αand pathohistology in group C were significantly different from those in group A and B. Conclusion Ulinnastation could markedly improve the prognosis of acute necrotic pancreatitis. |
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| Keywords: | acute necrotic pancreatitis ulinnastation animal model |
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