| 白花前胡甲素对豚鼠单一心室肌细胞钙电流的频率依赖性阻断作用 |
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| 引用本文： | 郝丽英,李金鸣,常天辉,孙晓东,王玉萍,张克义. 白花前胡甲素对豚鼠单一心室肌细胞钙电流的频率依赖性阻断作用[J]. 中国药理学与毒理学杂志, 1996, 0(1) |
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| 作者姓名： | 郝丽英 李金鸣 常天辉 孙晓东 王玉萍 张克义 |
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| 作者单位： | 中国医科大学基础医学部药理教研室 |
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| 基金项目： | the Science Foundation of Ministry of Public Health |
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| 摘 要： | 本文利用全细胞膜片钳制技术，观察了白花前胡有效成分Ｐｒａ－Ａ对豚鼠单一心室肌细胞钙电流的影响．结果表明：１，１０，１００μｍｏｌ·Ｌ－１Ｐｒａ－Ａ可使钙电流峰值变小，随浓度增加，作用加强；１０μｍｏｌ·Ｌ－１Ｐｒａ－Ａ对钙电流的抑制具使用依赖性和频率依赖性．结果提示Ｐｒａ－Ａ对钙电流的阻断作用可能是白花前胡抗心律失常作用的机理之一；Ｐｒａ－Ａ可能对快速型心律失常有防治作用．
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| 关 键 词： | 白花前胡甲素；膜片钳；钙通道；钙通道阻断剂；频率依赖性 |
Frequency-dependent block of calcium current by (±)- praeruptorin A in single ventricular cell of guinea pig |
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| HAO Li-Ying,LI Jin-Ming,CHANG Tian-Hui,SUN Xiao-Dong,WANG Yu-Ping,ZHANG Ke-Yi. Frequency-dependent block of calcium current by (±)- praeruptorin A in single ventricular cell of guinea pig[J]. Chinese Journal of Pharmacology and Toxicology, 1996, 0(1) |
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| Authors: | HAO Li-Ying LI Jin-Ming CHANG Tian-Hui SUN Xiao-Dong WANG Yu-Ping ZHANG Ke-Yi |
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| Abstract: | ?-Praeruptorin A (Pra-A) is an effective component of Peucedanum praeruptorum Dunn, a Chinese traditional medicine. In present study, the effects of Pra-A on calcium current (I Ca ) in single ventricular cells of guinea pig heart were examined by using whole-cell patch clamp technique. The results showed that Pra-A (1, 10 and 100 μmol·L -1 ) decreased I Ca in a concentration-dependent manner, and that Pra-A (10 μmol·L -1 ) inhibited I Ca in a use-dependent and a frequency-dependent manner. These results suggested that Pra-A had a calcium channel blocking effect and Pra-A might be promising in the treatment of tachyarrhythmia. |
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| Keywords: | Peucedanum praeruptorum Dunn (±)-preaeruptorin A patch clamp technique calcium channel calcium channel blockers frequency-dependency |
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