| 用草原兔尾鼠复制内脏利什曼病模型初探 |
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| 引用本文： | 杨元清,王革.用草原兔尾鼠复制内脏利什曼病模型初探[J].实验动物与比较医学,1995,15(2):82-84. |
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| 作者姓名： | 杨元清 王革 |
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| 作者单位： | 中国预防医学科学院寄生虫病研究所，新疆维吾尔自治区地方病防治研究所 |
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| 摘 要： | 给草原兔尾鼠经腹腔接种婴儿利什曼原虫前鞭毛体，５个月后剖杀动物作病理组织学检查，发现动物的脾、肝、骨髓、淋巴结、肾及输尿管内均有不同数量的利什曼原虫分布，有典型的内脏利什曼病病理损害。作者认为草原兔尾鼠是一种便于复制内脏利什曼病模型的动物。
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| 关 键 词： | 草原兔尾鼠 内脏利什曼病 动物模型 |
Duplication of Visceral Leishmaniasis Model in Lagurus Lagurus |
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| Yang Yuan-qing,Guan Li-ren,Wu Jia-tong.Duplication of Visceral Leishmaniasis Model in Lagurus Lagurus[J].Laboratory Animal and Comparative Medicine,1995,15(2):82-84. |
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| Authors: | Yang Yuan-qing Guan Li-ren Wu Jia-tong |
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| Abstract: | Three animals (Lagurus lagurus)obtained from Tian Shan area in Xinjiang were inoculated intraperitoneally with Leishmania infantum isolated from Phlebotomus major wui in Xiao Guai area, and were killed for histopathological examination 5months after the inoculation.The results showed that various numbers of Leishmania were found in spleen, liver, bone-marrow, lymphonodi, kidneys and ureters,and induced similar histopathological changes as seen in human visceral leishmaniasis,suggesting that L. lagurus might be a kind of ideal experimental animal for the duplication of visceral leisbmaniasis. |
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| Keywords: | Lagurus lagurus Leishmania infantum Visceral leishmaniasis Animal model Histopathological change |
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