| ARB改善胰岛素抵抗的研究进展 |
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| 引用本文： | 闫文华,窦京涛,潘长玉.ARB改善胰岛素抵抗的研究进展[J].国际内分泌代谢杂志,2008,28(5). |
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| 作者姓名： | 闫文华 窦京涛 潘长玉 |
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| 作者单位： | 解放军总医院内分泌科,北京,100853;解放军总医院内分泌科,北京,100853;解放军总医院内分泌科,北京,100853 |
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| 摘 要： | 血管紧张素受体拮抗剂(ARB)是一类作用于受体水平的抗高血压药物,可通过扩张外周血管提高组织血流灌注、增强葡萄糖向外周胰岛素敏感组织的转运和摄取、促进脂肪细胞分化、抑制脂肪组织炎性反应、减轻游离脂肪酸毒性作用、减少交感神经兴奋,拮抗氧化应激反应和调节基因表达.因而具有增强胰岛素敏感性,改善胰岛素抵抗的作用,为2型糖尿病合并高血压的治疗开辟了更广阔的前景.
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| 关 键 词： | 血管紧张素受体拮抗剂 胰岛素抵抗 炎性因子 2型糖尿病 |
Recent progress of ARB in improving insulin resistance |
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| YAN Wen-hua,DOU Jing-tao,PAN Chang-yu.Recent progress of ARB in improving insulin resistance[J].International JOurnal of Endocrinology and Metabolism,2008,28(5). |
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| Authors: | YAN Wen-hua DOU Jing-tao PAN Chang-yu |
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| Abstract: | Angiotensin receptor blocker(ARB)is acting as an antihypertensive drug at the receptor level.Because of its important roles in improving insulin resistance through dilating the blood vassels via increasing the peripheral tissue perfusion,enhancing the glucose transport and uptake by tissue sensitive to insulin,promoting preadipocyte differentiation,inhibiting the inflammation of the adipose tissue,decreasing the toxicity of free fatty acid,blocking the oxidative stress reaction and modulating the gene expression of angiotensin Ⅱ,ARB has opened up broad prospects for the treatment of type 2 diabetes mellitus with hypertension. |
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| Keywords: | Angiotensin receptor blocker Insulin resistance Inflammatory cytokines Type 2 diabetes mellitus |
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