| 碳酸酐酶Ⅲ自身抗体在 1 型糖尿病人中的测定简 |
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| 引用本文： | 刘辰庚,夏鸣,孟双,王培昌. 碳酸酐酶Ⅲ自身抗体在 1 型糖尿病人中的测定简[J]. 临床和实验医学杂志, 2014, 0(1): 24-26 |
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| 作者姓名： | 刘辰庚 夏鸣 孟双 王培昌 |
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| 作者单位： | [1]首都医科大学宣武医院检验科,北京100053 [2]上海闵行区中心医院检验科,上海201100 [3]中国疾病预防控制中心传染病预防控制所,北京102206 |
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| 摘 要： | 目的 探讨1型糖尿病（T1D）患者血清抗碳酸酐酶Ⅲ自身抗体水平的变化及其与抗氧化物、细胞因子之间的关系.方法 选取T1D患者共368例（T1D组）,另选取性别年龄匹配的健康受试者为对照组,测定其血清抗碳酸酐酶Ⅲ自身抗体、红细胞沉降率、超氧化物歧化酶（SOD）等4种抗氧化物和白细胞介素（IL）-2等4种细胞因子的水平.结果 T1D患者血清抗碳酸酐酶Ⅲ自身抗体水平显著高于健康对照组（P＜0.05）;T1D患者的SOD、谷胱甘肽过氧化物酶（GPx）和丙二醛（MDA）水平显著低于健康对照组（P＜0.05）;T1D患者的IL-2、IL-3和干扰素（IFN）-γ显著高于健康对照组（P＜0.05）.结论 抗氧化物和细胞因子水平的变化可能参与了T1D患者碳酸酐酶Ⅲ抗体的产生.
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| 关 键 词： | 1型糖尿病 自身抗体 碳酸酐酶Ⅲ 细胞因子 抗氧化物 |
The detection of carbonic anhydrase III auto-antibody in patients with type 1 diabetes |
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| Affiliation: | LIU Chen - geng1 , X1A Ming2, MENG Shnang3 et al. 1 Clinical Laboratory of Xuanwu Hospital, Captital Medcial University, Beijing 100053, China; 2 Central Hospital of Minhang District, Shanghai 201100, China ; 3 State Key Laboratory for Infectious Disease Prevention and Control, Chinese Center for Disease Control and Prevention, Beijing 102206, China. |
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| Abstract: | Objective To determine the carbonic anhydrase Ⅲ auto - antibody, the level of cytokines and antioxidants in the patients with type 1 diabetes （T1D）. Methods Total 158 T1D patients were included into this study. The anhydrase Ⅲ auto -antibody, the level of 4 kinds of cytokines （IL-2, etc）, 6 kinds of antioxidants （SOD, etc） and erythrocyte sedimentation rate were detected in all these patients. Re- suits The levels of anhydrase Ⅲ auto - antibody, IL - 2, IL - 3 and IFN - T in T1D patients were significantly higher than that in control group （ P 〈0. 05）. The levels of SOD and GPx in T1D patients were significantly lower than that in control group （ P 〈0. 05 ）. Conclusion The change of the levels of cytokines and antioxidants may take part in the generation of carbonic anhydrase Ⅲ auto - antibody in T1D patients. |
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| Keywords: | Type 1 diabetes Carbonic anhydrase III Auto - antibody Cytokines Antioxidant |
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