High frequency of c-K-ras activation in 3-methylcholanthrene-induced mouse thymomas |
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| Authors: | Eva Alessandra; Trimmer Roy W |
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| Institution: | Laboratory of Cellular and Molecular Biology, National Cancer Institute Building 37, Room 1E24, Bethesda, MD 20892, USA |
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| Abstract: | Thymic lymphomas were induced in RJF mice by percutaneous applicationof 3-methykholanthrene (MCA). DNAs from 83% of the tumors analyzedcontained a transforming c-K-ras gene. The high frequency ofc-K-ras oncogene activation in response to MCA seems to favorthe concept that the activation of c-K-ras is related to thespecificity of the mutagenic effect of MCA. |
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